77278-93-4

Basic information

• Product Name: 1-(TERT-BUTOXYCARBONYL)-4-((2-PYRIDYL)METHYL)PIPERAZINE
• Synonyms: 1-(TERT-BUTOXYCARBONYL)-4-((2-PYRIDYL)METHYL)PIPERAZINE;TERT-BUTYL-4-((PYRIDIN-2-YL)METHYL)PIPERAZINE-1-CARBOXYLATE
• CAS NO: 77278-93-4
• Molecular Formula: C₁₅H₂₃N₃O₂
• Molecular Weight: 277.36202
• Mol File: 77278-93-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 368.956°C at 760 mmHg
• Flash Point: 176.939°C
• Appearance: /
• Density: 1.122g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.541
• CAS DataBase Reference: 1-(TERT-BUTOXYCARBONYL)-4-((2-PYRIDYL)METHYL)PIPERAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(TERT-BUTOXYCARBONYL)-4-((2-PYRIDYL)METHYL)PIPERAZINE(77278-93-4)
• EPA Substance Registry System: 1-(TERT-BUTOXYCARBONYL)-4-((2-PYRIDYL)METHYL)PIPERAZINE(77278-93-4)

Safety Data

• Hazardous Substances Data: 77278-93-4(Hazardous Substances Data)

Usage

General Description

1-(tert-butoxycarbonyl)-4-((2-pyridyl)methyl)piperazine is a chemical compound with a complex structure consisting of a piperazine ring substituted with a tert-butoxycarbonyl group and a 2-pyridylmethyl group. It is commonly used in the synthesis of pharmaceuticals and organic compounds. The tert-butoxycarbonyl group is a protecting group commonly used in organic synthesis to temporarily mask reactive functional groups, while the 2-pyridylmethyl group is a common substituent found in various pharmaceutical compounds. 1-(TERT-BUTOXYCARBONYL)-4-((2-PYRIDYL)METHYL)PIPERAZINE has potential applications in medicinal chemistry and drug development, and its unique structure makes it a valuable building block for the synthesis of new chemical entities.

InChI:InChI=1/C15H23N3O2/c1-15(2,3)20-14(19)18-10-8-17(9-11-18)12-13-6-4-5-7-16-13/h4-7H,8-12H2,1-3H3

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 55579-01-6 1-(pyridine-2-ylmethyl)piperazine 
• 6959-47-3 2-chloromethylpyridine hydrochloride 
• 1121-60-4 pyridine-2-carbaldehyde 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 
• 55401-97-3 2-(Bromomethyl)pyridine 

Downstream Products

• 149691-83-8 1-(3-amino-3-phenylpropionyl)-4-[(2-methyl-pyridin-3-yl)cyanomethyl]piperazine 

Relevant articles and documents

PIPERAZINE DERIVATIVES FOR TREATING DISORDERS

Anti-angiogenic treatments, treatments of hyperpermeability disorders, treatments of neuropathic and neurodegenerative disorders, pain treatments, methods of reducing the risk of pre-eclampsia and compounds for use in such methods are described.

Discovery of 3-aryl-5-acylpiperazinyl-pyrazoles as antagonists to the NK3 receptor

A series of 3-aryl-5-acylpiperazinyl-pyrazoles (e.g., 3a-b) initially identified through a high-throughput screening campaign using the aequorin Ca2+ bioluminescence assay as novel, potent small molecule antagonists of the G protein-coupled hum

(2-Alkyl-3-pyridyl)methylpiperazine derivatives as PAF antagonists

The present invention relates to new (2-alkyl-3-pyridyl) methylpiperazine derivatives of general formula I: wherein R1, R2 and Z are as defined in Claim 1. The invention also relates to processes for their preparation and to pharmaceutical compositions containing them. These compounds are potent, orally active PAF antagonists and, consequently, they are useful in the treatment of the diseases in which this substance is involved.