77287-58-2

Basic information

• Product Name: 2-Iodo-5-methoxybenzaldehyde
• Synonyms: 2-Iodo-5-methoxybenzaldehyde;2-Iodo-5-methoxybenzaldehyd
• CAS NO: 77287-58-2
• Molecular Formula: C₈H₇IO₂
• Molecular Weight: 262.04445
• Product Categories: Building Blocks;C2 to C8;Chemical Synthesis;Ethers;New Products for Chemical Synthesis;Organic Building Blocks;Oxygen Compounds;aldehyde| alkyl Iodine
• Mol File: 77287-58-2.mol
• Article Data: 22

Chemical Properties

• Melting Point: 110-115℃
• Appearance: White to off-white to yellow/Solid
• Sensitive: Air & Light Sensitive
• CAS DataBase Reference: 2-Iodo-5-methoxybenzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Iodo-5-methoxybenzaldehyde(77287-58-2)
• EPA Substance Registry System: 2-Iodo-5-methoxybenzaldehyde(77287-58-2)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• WGK Germany: 3
• Hazardous Substances Data: 77287-58-2(Hazardous Substances Data)

Usage

General Description

2-Iodo-5-methoxybenzaldehyde, also known as 5-Methoxy-2-iodobenzaldehyde, is a chemical compound with the molecular formula C8H7IO2. It is a white to light yellow crystalline powder that is primarily used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. The presence of the iodo and methoxy groups on the benzene ring make this compound suitable for use in various organic transformations, including nucleophilic substitution and aromatic coupling reactions. It is also known for its potential as a starting material for the synthesis of biologically active compounds and as a building block for the development of new drugs. However, it is important to handle this compound carefully as it is potentially harmful if inhaled or ingested and can cause irritation to the skin and eyes.

Upstream product

• 139557-96-3 (2-iodo-5-methoxyphenyl)methanol 
• 591-31-1 3-methoxy-benzaldehyde 
• 6971-51-3 3-methoxybenzyl alcohol 
• 54413-93-3 2-iodo-5-methoxybenzoic acid 
• 6705-03-9 2-Amino-5-methoxybenzoic acid 
• 150192-39-5 2-Bromo-5-methoxybenzyl alcohol 
• 7507-86-0 2-bromo-5-methoxy-benzaldehyde 

Downstream Products

• 105728-92-5 5,10,15,20-tetrakis(2-iodo-5-methoxyphenyl)porphyrin 
• 98751-26-9 2-t-butoxy-5-methoxybenzaldehyde 
• 72525-51-0 2-iodo-5-methoxystyrene oxide 
• 213599-27-0 2-(2,2-Dibromo-vinyl)-1-iodo-4-methoxy-benzene 
• 265308-37-0 4-[(Z)-1-Ethoxycarbonyl-2-(2-iodo-5-methoxy-phenyl)-vinylamino]-benzoic acid ethyl ester 
• 132901-31-6 4,4′-dimethoxy[1,1′-biphenyl]-2,2′-dicarbaldehyde 
• 118545-81-6 4,4'-bis-(2H-chromen-2-one) 
• 672-13-9 2-hydroxy-5-methoxybenzaldehyde 
• 52289-54-0 4-methoxysalicylaldehyde 
• 6245-57-4 4-methoxy-2-methylbenzoic acid 
• 1206626-36-9 ethyl 2-azido-3-(2-iodo-5-methoxyphenyl)acrylate 
• 58755-70-7 1-iodo-4-methoxy-2-nitrobenzene 
• 1235340-59-6 C₁₇H₁₄O₂S 

Relevant articles and documents

INHIBITORS OF PURINE NUCLEOSIDE PHOSPHORYLASE - SYNTHESIS AND USE THEREOF FOR TREATMENT OF T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA AND LYMPHOMA

The present invention relates to new compounds of general formula I, their synthesis, their pharmaceutically acceptable salts, and their use in treatment of T-cell acute lymphoblastic leukemia and lymphoma.

One-pot synthesis of hypervalent diaryl(iodo)bismuthanes from o-carbonyl iodoarenes by zincation

Diaryl(iodo)bismuthanes possessing a hypervalent C=O???Bi-I bond were conveniently synthesized in a one-pot reaction by using arylzinc reagents generated from o-carbonyl iodobenzenes and zinc powder under ultrasonication. This method is superior to the conventional organolithium and Grignard methods because it has a wide functional group tolerance, requires no protecting group manipulations, and proceeds under mild reaction conditions that do not need low temperature control. Furthermore, no intermediate triarylbismuthane precursor for the hypervalent iodobismuthane is necessary.

Disulfide-Catalyzed Iodination of Electron-Rich Aromatic Compounds

Herein, a disulfide-catalyzed electrophilic iodination of aromatic compounds using 1,3-diiodo-5,5-dimethylhydantoin (DIH) has been developed. The disulfide activates DIH as a Lewis base to promote the iodination reaction in acetonitrile under mild conditions. This system is applicable to a wide range of electron-rich aromatic compounds, including acetanilide, anisole, imidazole, and pyrazole derivatives.