77344-61-7

Basic information

• Product Name: 1-[2,4-bis(1-methylethyl)phenyl]ethan-1-one
• Synonyms: 1-[2,4-bis(1-methylethyl)phenyl]ethan-1-one;1-[2,4-Bis(1-methylethyl)phenyl]ethanone
• CAS NO: 77344-61-7
• Molecular Formula: C₁₄H₂₀O
• Molecular Weight: 204.308
• EINECS: 278-670-0
• Mol File: 77344-61-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 296°C at 760 mmHg
• Flash Point: 121.1°C
• Appearance: /
• Density: 0.924g/cm³
• Vapor Pressure: 0.00148mmHg at 25°C
• Refractive Index: 1.496
• CAS DataBase Reference: 1-[2,4-bis(1-methylethyl)phenyl]ethan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[2,4-bis(1-methylethyl)phenyl]ethan-1-one(77344-61-7)
• EPA Substance Registry System: 1-[2,4-bis(1-methylethyl)phenyl]ethan-1-one(77344-61-7)

Safety Data

• Hazardous Substances Data: 77344-61-7(Hazardous Substances Data)

Usage

Category

Synthetic organic compound

Usage

a. Flavoring agent in the food industry
b. Fragrance in perfumes and personal care products

Odor

Characteristic sweet, floral, and balsamic odor with a fruity undertone

Industrial Applications

Used in the production of plastics and resins

Safety Precautions

Handle with care due to potential irritant and toxic effects if ingested or inhaled

InChI:InChI=1/C14H20O/c1-9(2)12-6-7-13(11(5)15)14(8-12)10(3)4/h6-10H,1-5H3

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Relevant articles and documents

Design, synthesis and biological evaluation of novel aryldiketo acids with enhanced antibacterial activity against multidrug resistant bacterial strains

Antimicrobial resistance (AMR) is a major health problem worldwide, because of ability of bacteria, fungi and viruses to evade known therapeutic agents used in treatment of infections. Aryldiketo acids (ADK) have shown antimicrobial activity against several resistant strains including Gram-positive Staphylococcus aureus bacteria. Our previous studies revealed that ADK analogues having bulky alkyl group in ortho position on a phenyl ring have up to ten times better activity than norfloxacin against the same strains. Rational modifications of analogues by introduction of hydrophobic substituents on the aromatic ring has led to more than tenfold increase in antibacterial activity against multidrug resistant Gram positive strains. To elucidate a potential mechanism of action for this potentially novel class of antimicrobials, several bacterial enzymes were identified as putative targets according to literature data and pharmacophoric similarity searches for potent ADK analogues. Among the seven bacterial targets chosen, the strongest favorable binding interactions were observed between most active analogue and S. aureus dehydrosqualene synthase and DNA gyrase. Furthermore, the docking results in combination with literature data suggest that these novel molecules could also target several other bacterial enzymes, including prenyl-transferases and methionine aminopeptidase. These results and our statistically significant 3D QSAR model could be used to guide the further design of more potent derivatives as well as in virtual screening for novel antibacterial agents.

The colored curable composition, and its manufacturing method, a color filter, a liquid crystal display device, a solid-state imaging device, and, a dye compd.

Provided is a curable colored composition, transmitting the light in the magenta region and absorbing the light in the cyan region. A curable colored composition comprising a metal complex in which a compound represented by formula (I) below is coordinated to a metal atom or a metal compound.