77354-99-5Relevant articles and documents
Synthesis, antitumor activity, enzyme assay, DNA binding and molecular docking of Bis-Schiff bases of pyrazoles
Morsy, Nesrin M.,Hassan, Ashraf S.,Hafez, Taghrid S.,Mahran, Mohamed R. H.,Sadawe, Inass A.,Gbaj, Abdul M.
, p. 47 - 59 (2020/07/27)
A novel series of Bis-Schiff bases of pyrazoles 9–24 were synthesized by the direct condensation of 5-aminopyrazoles 4a–d with dialdehydes 8a–d in ethanol. The newly synthesized Bis-Schiff bases of pyrazoles 9–24 were characterized and confirmed by analyt
A rapid synthesis of low-nanomolar divalent LecA inhibitors in four linear steps from d-galactose pentaacetate
Hirsch, Anna K. H.,Imberty, Anne,Kinsinger, Thorsten,Kuhaudomlarp, Sakonwan,Lepsik, Martin,Minervini, Saverio,Titz, Alexander,Yousaf, Sultaan,Zahorska, Eva
, p. 8822 - 8825 (2020/08/17)
Chronic infections with Pseudomonas aeruginosa are associated with the formation of bacterial biofilms. The tetrameric P. aeruginosa lectin LecA is a virulence factor and an anti-biofilm drug target. Increasing the overall binding affinity by multivalent
Y-shaped bis-arylethenesulfonic acid esters: Potential potent and membrane permeable protein tyrosine phosphatase 1B inhibitors
Yang, Fengzhi,Xie, Fangzhou,Zhang, Ying,Xia, Yu,Liu, Wenlu,Jiang, Faqin,Lam, Celine,Qiao, Yixue,Xie, Dongsheng,Li, Jianqi,Fu, Lei
supporting information, p. 2166 - 2170 (2017/04/27)
Known PTP1B inhibitors with bis-anionic moieties exhibit potent inhibitory activity, good selectivity, however, they are incapable of penetrating cellular membranes. Based upon our finding of a new pharmacophoric group in inhibition of PTP1B and the struc
