77385-75-2

Basic information

• Product Name: (E)-β-(3,5-dimethylphenyl)vinyl bromide
• CAS NO: 77385-75-2
• Molecular Weight: 211.101
• Mol File: 77385-75-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (E)-β-(3,5-dimethylphenyl)vinyl bromide(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-β-(3,5-dimethylphenyl)vinyl bromide(77385-75-2)
• EPA Substance Registry System: (E)-β-(3,5-dimethylphenyl)vinyl bromide(77385-75-2)

Safety Data

• Hazardous Substances Data: 77385-75-2(Hazardous Substances Data)

Upstream product

• 64781-23-3 3,5-Dimethyl-zimtsaeure 
• 5379-20-4 3,5-dimethylstyrene 

Relevant articles and documents

Cyclic Diaryl λ3-Bromanes: A Rapid Access to Molecular Complexity via Cycloaddition Reactions

Biaryls have widespread applications in organic synthesis. However, sequentially polysubstituted biaryls are underdeveloped due to their challenging preparation. Herein, we report the synthesis of dissymetric 2,3,2′,3′,4-substituted biaryls via pericyclic reactions of cyclic diaryl λ3-bromanes. The functional groups tolerance and atom economy allow access to molecular complexity in a single reaction step. Continuous flow protocol has been designed for the scale-up of the reaction, while postfunctionalizations have been developed taking advantage of the residual Br-atom.