77400-65-8 Usage
Originator
Asocainol,ZYF Pharm
Uses
Different sources of media describe the Uses of 77400-65-8 differently. You can refer to the following data:
1. Asocainol (ASOC) belongs to class I antiarrhythmic drugs, i.e., those that exert their action at the level of sodium channels of the myocardial cell membrane.
2. Labelled Asocainol
Manufacturing Process
A solution of a Grignard reagent is prepared from 5.5 g (0.23 mol) activated
magnesium turnings and 41.5 g (0.24 mol) phenethyl bromide in 200 ml
anhydrous diethyl ether. To this is added dropwise, at 35-40°C, a solution of
31.5 g (0.1 mol) thebaine in 0.4 liters dry benzene. After heating under reflux
for 2 hours, the reaction mixture is decomposed with a solution of 48 g
ammonium chloride in 200 ml water. The usual working up, after conversion
of the base into the hydrochloride by means of hydrogen chloride in ethyl
acetate, gives 7.3 g (21% of theory) (+/-)-2,12-dimethoxy-1-hydroxy-7-
methyl-6-phenethyl-5,6,8,9-tetrahydro-7H-dibenz[d,f]azonine hydrochloride,
melting point 227.6°C, after recrystallization from propan-2-ol.
Check Digit Verification of cas no
The CAS Registry Mumber 77400-65-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,7,4,0 and 0 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 77400-65:
(7*7)+(6*7)+(5*4)+(4*0)+(3*0)+(2*6)+(1*5)=128
128 % 10 = 8
So 77400-65-8 is a valid CAS Registry Number.
InChI:InChI=1/C27H31NO3/c1-28-16-15-20-10-13-23(30-2)18-24(20)26-21(11-14-25(31-3)27(26)29)17-22(28)12-9-19-7-5-4-6-8-19/h4-8,10-11,13-14,18,22,29H,9,12,15-17H2,1-3H3
