774218-66-5Relevant articles and documents
SAR and factor IXa crystal structure of a dual inhibitor of factors IXa and Xa
Smallheer, Joanne M.,Alexander, Richard S.,Wang, Jianmin,Wang, Shuaige,Nakajima, Suanne,Rossi, Karen A.,Smallwood, Angela,Barbera, Frank,Burdick, Debra,Luettgen, Joseph M.,Knabb, Robert M.,Wexler, Ruth R.,Jadhav, Prabhakar K.
, p. 5263 - 5267 (2007/10/03)
An X-ray crystal structure of compound 3b complexed to fIXa shows a similar binding mode to that previously observed with pyrazole inhibitors in the fXa active site. The best combination of fIXa potency and selectivity in this series was obtained with 5-c
