77426-90-5

Basic information

• Product Name: α,α-diethoxybenzeneacetonitrile
• Synonyms: α,α-diethoxybenzeneacetonitrile
• CAS NO: 77426-90-5
• Molecular Weight: 205.257
• Mol File: 77426-90-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: α,α-diethoxybenzeneacetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: α,α-diethoxybenzeneacetonitrile(77426-90-5)
• EPA Substance Registry System: α,α-diethoxybenzeneacetonitrile(77426-90-5)

Safety Data

• Hazardous Substances Data: 77426-90-5(Hazardous Substances Data)

Upstream product

• 74-90-8 hydrogen cyanide 
• 1663-61-2 triethoxymethylbenzene 
• 631-57-2 Acetyl cyanide 
• 100-47-0 benzonitrile 

Downstream Products

• 77426-94-9 1-(Diethoxy-phenyl-methyl)-pentylamine 
• 73611-86-6 1,1-diethoxy-1-phenyl-2-propanone 
• 25871-56-1 diethoxy-phenyl-acetaldehyde 
• 74209-49-7 2-Phenyl-2,2-diethoxyethylamine 

Relevant articles and documents

A FACILE ROUTE TO α-IMINO ACETALS AND THE CORRESPONDING MONOACETAL DERIVATIVES OF α-DIKETONES WITH COMPLETE REGIOCHEMICAL CONTROL

Treatment of representative orthoesters (2) with pyruvonitrile (3) afforded the corresponding α,α-diethoxynitriles (4) in 65-80percent yields.Depending upon the conditions used to protonate the initial adduct, subsequent addition of an organolithium (5) or Grignard reagent to the latter (4) led to the obtention of either α-imino acetals (6) or the corresponding monoprotected α-diketones (7) in >90percent yield.

AN EXPEDITIOUS ROUTE TO MONOPROTECTED α-KETO ALDEHYDES WITH CONTROL OF REGICHEMISTRY

Treatment of representative orthoesters (2) with pyruvonitrile (3) afforded the corresponding α,α-diethoxynitriles (4) in 65-85percent yields.Subsequent reduction of the latter using lithium aluminium hydride, followed by careful hydrolysis of the aldimine intermediates, led to the procurement of α,α-doalkoxy aldehydes (5) in 80-90percent yield.