774490-79-8

Basic information

• Product Name: 1-Benzyl-3-broMo-piperidine
• Synonyms: 1-Benzyl-3-broMo-piperidine
• CAS NO: 774490-79-8
• Molecular Formula: C₁₂H₁₆BrN
• Molecular Weight: 254.16614
• Mol File: 774490-79-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-Benzyl-3-broMo-piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Benzyl-3-broMo-piperidine(774490-79-8)
• EPA Substance Registry System: 1-Benzyl-3-broMo-piperidine(774490-79-8)

Safety Data

• Hazardous Substances Data: 774490-79-8(Hazardous Substances Data)

Usage

Chemical class

Piperidine class of compounds

Structural features

Presence of a benzyl group and a bromine atom

Primary use

Intermediate in the synthesis of pharmaceuticals and agrochemicals

Potential applications

a. Organic building block in the development of new drugs
b. Field of neuroscience and psychopharmacology
c. Synthesis of various bioactive molecules
d. Precursor for the synthesis of heterocyclic compounds

Importance

a. Medicinal chemistry
b. Organic synthesis
These properties and specific content are based on the information provided, which highlights the compound's role in the development of new drugs, its potential in the synthesis of bioactive molecules, and its significance in the fields of medicinal chemistry and organic synthesis.

Upstream product

• 285-76-7 1-azabicyclo[3.1.0]hexane 
• 100-39-0 benzyl bromide 
• 54436-58-7 N-benzylpent-4-en-1-amine 
• 1119-51-3 bromopentene 
• 100-46-9 benzylamine 

Relevant articles and documents

Regioselective copper(II)-mediated bromoamination of unfunctionalized olefins: An efficient route to N-heterocyclic compounds

Bromoamination of unfunctionalized olefins was realized under mild conditions using copper(II) bromide (CuBr2) as both reaction promoter and bromine source. The reactions could be carried out under open air at ambient temperature, and both N-alkylated and N-tosylated substrates could be converted to the corresponding N-heterocyclic compounds in high regioselectivity and good isolated yields. A variety of biologically important structures could be obtained via subsequent nucleophilic substitution reactions.

Synthesis and reaction of 1-azabicyclo[3.1.0]hexane

The effective formation of 1-azabicyclo[3.1.0]hexane (5) by treatment of 2-(bromomethyl)pyrrolidine hydrobromide (4) with n-BuLi was established, with the reaction occurring by a rational reaction pathway via the open chain transition state 8 based on int