774549-97-2 Usage
Description
KM 11060 is a small molecular corrector specifically designed to address the F508del CFTR trafficking issue, a common genetic mutation associated with cystic fibrosis. KM 11060 has shown promise in the development of therapeutic strategies for individuals suffering from this genetic disorder.
Uses
Used in Pharmaceutical Industry:
KM 11060 is used as a therapeutic agent for the treatment of cystic fibrosis. It targets the F508del CFTR trafficking defect, which is a primary cause of the disease. By correcting this defect, KM 11060 has the potential to alleviate the symptoms and improve the quality of life for patients with cystic fibrosis.
Biological Activity
Corrects F508del-CFTR trafficking; increases the amount of functional CFTR at the plasma membrane (~75%). Shown to inhibit PDE5 activity.
Check Digit Verification of cas no
The CAS Registry Mumber 774549-97-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,7,4,5,4 and 9 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 774549-97:
(8*7)+(7*7)+(6*4)+(5*5)+(4*4)+(3*9)+(2*9)+(1*7)=222
222 % 10 = 2
So 774549-97-2 is a valid CAS Registry Number.
InChI:InChI=1/C19H17Cl2N3O2S/c20-14-1-4-16(5-2-14)27(25,26)24-11-9-23(10-12-24)19-7-8-22-18-13-15(21)3-6-17(18)19/h1-8,13H,9-12H2
774549-97-2Relevant articles and documents
Synthesis and evaluation of 7-chloro-4-(piperazin-1-yl)quinoline- sulfonamide as hybrid antiprotozoal agents
Salahuddin, Attar,Inam, Afreen,Van Zyl, Robyn L.,Heslop, Donovan C.,Chen, Chien-Teng,Avecilla, Fernando,Agarwal, Subhash M.,Azam, Amir
, p. 3080 - 3089 (2013/07/05)
A new series of 4-aminochloroquinoline based sulfonamides were synthesized and evaluated for antiamoebic and antimalarial activities. Out of the eleven compounds evaluated (F1-F11), two of them (F3 and F10) showed good activity against Entamoeba histolyti
