774576-70-4Relevant articles and documents
Palladium-catalyzed cross-coupling of aryl electrophiles with dimethylalkynylaluminum reagents
Wang, Baomin,Bonin, Martine,Micouin, Laurent
, p. 3481 - 3484 (2004)
(Chemical Equation Presented) Alkynyldimethylaluminum reagents are easily available from terminal akynes and trimethylaluminum via a triethylamine- catalyzed metalation. These compounds can react with various aromatic and heterocyclic halides in the presence of palladium in a fast and efficient way. This catalyzed cross-coupling reaction provides a simple entry to numerous internal alkynes, using a readily available, inexpensive, and nontoxic metalating agent.