77469-44-4Relevant articles and documents
New oncostatic nitrosourea of clinical interest. I. Synthesis and identification of CNCC
Oiry,Imbach
, p. 305 - 309 (2007/10/02)
This paper describes CNCC synthesis, a mixture of the three nitrosourea isomer corresponding to cystamine as the starting compound. The regioselective synthesis of one of these isomeric products is described and the structure of this compound is determined by the usual analytical approaches: NMR, HPLC.
Activated N-Nitrosocarbamates for Regioselective Synthesis of N-Nitrosoureas
Martinez, Jean,Oiry, Joel,Imbach, Jean Louis,Winternitz, Francois
, p. 178 - 182 (2007/10/02)
A practical and convenient method for synthesizing antitumor compounds, N-alkyl-N-nitrosoureas, regioselectively nitrosated on the nitrogen atom bearing the alkyl group is proposed.N-Alkyl-N-nitrosocarbamates are interesting intermediates in these syntheses and yield, by reaction with amino compounds, the regioselectively nitrosated N-alkyl-N-nitrosoureas.As an interesting example, N,N'-biscystamine, a new attractive oncostatic derivative, has been prepared.The cytotoxic activity of these various compounds were tested on L1210 leukemia.