77481-28-8

Basic information

• Product Name: N-Methyl-D-glutamic acid
• Synonyms: (R)-2-(Methylamino)pentanedioic acid;N-Methyl-D-glutamic acid;N-Methyl-D-glutamate;N-Me-D-Glu-OH
• CAS NO: 77481-28-8
• Molecular Formula: C6H11NO4
• Molecular Weight: 161.16
• Product Categories: amino acids
• Mol File: 77481-28-8.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 330.2 °C at 760 mmHg
• Flash Point: 153.5 °C
• Appearance: /
• Density: 1.278
• Storage Temp.: 2-8°C
• CAS DataBase Reference: N-Methyl-D-glutamic acid(CAS DataBase Reference)
• NIST Chemistry Reference: N-Methyl-D-glutamic acid(77481-28-8)
• EPA Substance Registry System: N-Methyl-D-glutamic acid(77481-28-8)

Safety Data

• Hazardous Substances Data: 77481-28-8(Hazardous Substances Data)

Usage

General Description

N-Methyl-D-glutamic acid is a chemical compound that is a derivative of the amino acid glutamic acid. It is a methylated form of glutamic acid and is commonly used in the synthesis of various peptides and proteins. N-Methyl-D-glutamic acid is known to have a role in the modulation of neurotransmission and has been studied for its potential use in the treatment of neurological disorders. It has also been investigated for its potential as a therapeutic agent in drug delivery systems and as a building block for pharmaceutical compounds. Overall, N-Methyl-D-glutamic acid is a versatile compound with a variety of potential applications in the field of medicine and biotechnology.

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Relevant articles and documents

Stellettapeptins A and B, HIV-inhibitory cyclic depsipeptides from the marine sponge Stelletta sp.

Two new HIV-inhibitory depsipeptides, stellettapeptins A (1) and B (2), were isolated from an extract of the marine sponge Stelletta sp., collected from northwestern Australia. Structures of these cyclic nonribosomal peptides were elucidated on the basis of extensive NMR data analysis, and chemical degradation and derivatization studies. Stellettapeptins contain numerous nonproteinogenic amino acid residues and they are the first peptides reported to contain a 3-hydroxy-6,8-dimethylnon-4-(Z)-enoic acid moiety. Compounds 1 and 2 potently inhibit infection of human T-lymphoblastoid cells by HIV-1RF with EC50 values of 23 and 27 nM, respectively.

Cytotoxic cyclic depsipeptides from the Australian marine sponge Neamphius huxleyi

Three new cyclic depsipeptides, neamphamides B (2), C (3), and D (4), were isolated from the Australian sponge Neamphius huxleyi. The planar structural characterization of these molecules was elucidated using 2D NMR experiments and ESI-FTICR-MSn. Their configurations were determined by Marfey's method and J-based NMR analysis. These new metabolites inhibited the growth of human cell lines (A549, HeLa, LNCaP, PC3, and NFF) with IC50 values ranging from 88 to 370 nM. However, neamphamide D causes A549 cell proliferation at subcytotoxic doses and should be treated cautiously as a cytotoxic compound.

METHOD FOR PREPARING AMIDE

The present invention provides a method for preparing amides, in which an amino acid ionic liquid is used as both a reaction medium and a catalyst to catalyze Beckman rearrangement of a ketoxime, so as to produce an amide. In the method, the rearrangement is conducted by catalyzing a ketoxime with an amino acid ionic liquid having the asymmetric property at a moderate reaction temperature during a short reaction time, so as to produce an amide without adding other catalysts such as concentrate sulfuric acid. The method has advantages such as avoiding corrosion in equipments with pipelines, the high conversion rate of ketoximes and the high selectivity of amides.