775-08-6

Basic information

• Product Name: 3 5-DIMETHYLPHENYLPHOSPHORYL DICHLORIDE
• Synonyms: 3 5-DIMETHYLPHENYLPHOSPHORYL DICHLORIDE;1-dichlorophosphoryloxy-3,5-dimethylbenzene;1-dichlorophosphoryloxy-3,5-dimethyl-benzene
• CAS NO: 775-08-6
• Molecular Formula: C₈H₉Cl₂O₂P
• Molecular Weight: 239.04
• Mol File: 775-08-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 289.1°C at 760 mmHg
• Flash Point: 160°C
• Appearance: /
• Density: 1.355g/cm³
• Vapor Pressure: 0.00389mmHg at 25°C
• Refractive Index: 1.53
• CAS DataBase Reference: 3 5-DIMETHYLPHENYLPHOSPHORYL DICHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3 5-DIMETHYLPHENYLPHOSPHORYL DICHLORIDE(775-08-6)
• EPA Substance Registry System: 3 5-DIMETHYLPHENYLPHOSPHORYL DICHLORIDE(775-08-6)

Safety Data

• Hazardous Substances Data: 775-08-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H9Cl2O2P/c1-6-3-7(2)5-8(4-6)12-13(9,10)11/h3-5H,1-2H3

Upstream product

• 108-68-9 3,5-Dimethylphenol 

Downstream Products

• 109632-41-9 2-(3,5-Dimethyl-phenoxy)-3H-[1,3,2]oxazaphospholo[4,5-b]pyridine 2-oxide 
• 100032-46-0 7-(3,5-Dimethyl-phenoxy)-2,3-dimethyl-5,9-dihydro-6,8-dithia-7-phospha-benzocycloheptene 7-oxide 
• 105053-50-7 6-(3,5-Dimethyl-phenoxy)-5,7-dioxa-6-phospha-dibenzo[a,c]cycloheptene 6-oxide 
• 138650-15-4 2,10-Dichloro-6-(3,5-dimethyl-phenoxy)-12H-5,7-dioxa-6-phospha-dibenzo[a,d]cyclooctene 6-oxide 
• 137734-71-5 C₂₉H₂₃O₄P 
• 120628-05-9 2-(3,5-dimethylphenyloxy)-3-cyclohexyl-6-(1,1-dimethylethyl)-3,4-dihydro-2H-1,3,2-benzoxazaphosphorine-2-oxide 
• 77014-52-9 C₂₀H₁₉N₂O₃P 
• 125790-32-1 C₂₀H₁₇Cl₂N₂O₃P 
• 130557-91-4 4-(3,5-Dimethyl-phenoxy)-3,5-dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalene 4-oxide 
• 1030351-71-3 3,5-dimethylphenyldiamidophosphate 

Relevant articles and documents

Design, synthesis, and biological evaluation of phosphoramide derivatives as urease inhibitors

The design, synthesis, and biological evaluation of phosphoramide derivatives as urease inhibitors to reduce the loss of ammonia has been carried out. Forty phosphorus derivatives were synthesized and their inhibitory activities evaluated against that of jack bean urease. In addition, in vivo assays have been carried out. All of the compounds were characterized by IR, 1H NMR, MS, and elemental microanalysis. In some cases, detailed molecular modeling studies were carried out, and these highlighted the interaction between the enzyme active center and the compounds and also the characteristics related to their activity as urease inhibitors. According to the IC50 values for in vitro inhibitory activity, 12 compounds showed values below 1 μM and 8 of them represent improvements of activity in comparison to the commercial urease inhibitor N-n-butylthiophosphorictriamide (NBPT) (100 nM) (AGROTAIN). On the basis of the activity results and the conclusions of the molecular modeling study, a structural model for new potential inhibitors has been defined.