77523-95-6

Basic information

• Product Name: 1-(1H-benzimidazol-2-ylmethyl)-3-phenylthiourea
• CAS NO: 77523-95-6
• Molecular Formula: C₁₅H₁₄N₄S
• Molecular Weight: 282.3635
• Mol File: 77523-95-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 519.2°C at 760 mmHg
• Flash Point: 267.8°C
• Density: 1.373g/cm³
• Vapor Pressure: 6.96E-11mmHg at 25°C
• Refractive Index: 1.779
• CAS DataBase Reference: 1-(1H-benzimidazol-2-ylmethyl)-3-phenylthiourea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(1H-benzimidazol-2-ylmethyl)-3-phenylthiourea(77523-95-6)
• EPA Substance Registry System: 1-(1H-benzimidazol-2-ylmethyl)-3-phenylthiourea(77523-95-6)

Safety Data

• Hazardous Substances Data: 77523-95-6(Hazardous Substances Data)

Usage

Description

1-(1H-benzimidazol-2-ylmethyl)-3-phenylthiourea is a chemical compound belonging to the class of benzimidazole derivatives. It is characterized by a benzimidazole moiety connected to a phenylthiourea group via a methyl bridge. 1-(1H-benzimidazol-2-ylmethyl)-3-phenylthiourea has been the subject of research due to its potential biological activities, which include antimicrobial, antiproliferative, and antifungal properties. Additionally, it has been investigated for its possible use as an enzyme inhibitor and as a drug candidate for treating specific diseases. The synthesis, characterization, and structure-activity relationships of 1-(1H-benzimidazol-2-ylmethyl)-3-phenylthiourea have been documented in scientific literature, with a focus on its potential applications in medicinal chemistry and drug development.

Uses

Used in Pharmaceutical Industry:
1-(1H-benzimidazol-2-ylmethyl)-3-phenylthiourea is used as a potential drug candidate for the treatment of certain diseases due to its antimicrobial, antiproliferative, and antifungal properties. Its ability to inhibit various enzymes also contributes to its potential as a therapeutic agent.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 1-(1H-benzimidazol-2-ylmethyl)-3-phenylthiourea is utilized for research purposes, particularly in exploring its structure-activity relationships. This helps in understanding how the compound interacts with biological targets and can be optimized for specific therapeutic applications.
Used in Drug Development:
1-(1H-benzimidazol-2-ylmethyl)-3-phenylthiourea is also used in drug development, where its potential biological activities are harnessed to create new medications. The study of its interactions with enzymes and its ability to inhibit them make it a valuable asset in the development of novel therapeutics.
Used in Enzyme Inhibition Studies:
1-(1H-benzimidazol-2-ylmethyl)-3-phenylthiourea is employed as a potential enzyme inhibitor in various research studies. Its ability to inhibit specific enzymes can be crucial in understanding the underlying mechanisms of certain diseases and in developing targeted treatments.

Upstream product

• 5805-57-2 2-Aminomethylbenzimidazole 
• 103-72-0 phenyl isothiocyanate 
• 5993-91-9 2-(aminomethyl)benzimidazole dihydrochloride 

Downstream Products

• 77524-01-7 (3H-Benzo[d]imidazo[1,5-a]imidazol-1-yl)-phenyl-amine 
• 89334-78-1 3-[(1H-benzo[d]imidazol-2-yl) methyl]-2-(phenylimino)thiazolidin-4-one 
• 1375328-53-2 3-[(1H-benzo[d]imidazol-2-yl)methyl]-5-benzylidene-2-(phenylimino)thiazolidin-4-one 
• 1375328-54-3 3-[(1H-benzo[d]imidazol-2-yl)methyl]-5-(4-chlorobenzylidene)-2-(phenylimino)thiazolidin-4-one 
• 1375328-55-4 3-[(1H-benzo[d]imidazol-2-yl)methyl]-5-(4-nitrobenzylidene)-2-(phenylimino)thiazolidin-4-one 
• 1375328-56-5 3-[(1H-benzo[d]imidazol-2-yl)methyl]-5-(2-chlorobenzylidene)-2-(phenylimino)thiazolidin-4-one 
• 1375328-57-6 3-[(1H-benzo[d]imidazol-2-yl)methyl]-5-(-3-phenylallylidene)-2-(phenylimino)thiazolidin-4-one 
• 1375328-58-7 3-[(1H-benzo[d]imidazol-2-yl)methyl]-5-(2,5-dimethoxybenzylidene)-2-(phenylimino)thiazolidin-4-one 
• 1375328-59-8 3-[(1H-benzo[d]imidazol-2-yl)methyl]-5-(2,4-dimethoxybenzylidene)-2-(phenylimino)thiazolidin-4-one 

Relevant articles and documents

Design, synthesis, and biological evaluation of new 4-thiazolidinone derivatives substituted with benzimidazole ring as potential chemotherapeutic agents

In search of novel antiviral and anticancer agents with promising pharmacotoxicological profile, a study was initiated to synthesize new 2-thioxo-4-thiazolidinones as well as 2-phenylimino-4-thiazolidinones substituted with benzimidazole ring system. The compounds were screened primarily for their antiviral as well as anticancer activities. The synthesis of some novel 5-substituted thiazolidinones was also described. None of the tested compounds showed inhibitory activity against Hepatitis C virus replication. Two 2-phenylimino-4-thiazolidinone derivatives (9a and 10) exhibited significant antiproliferative activity against human colon carcinoma cell line HCT 116 and human hepatocellular carcinoma HEPG2 cell line, respectively. Results also indicated that six thiazolidinone derivatives (5a, 5d, 5e, 5f, 5h, and 9d) showed moderate antiproliferative activity against human breast adenocarcinoma cell line MCF7 in comparison to the standard drug Doxorubicin. Moreover, a docked pose of the most potent three cytotoxic compounds 5a, 5h, and 9d against MCF7 was obtained bound to Human N-acetyl transferase1 NAT1 binding pocket by molecular operating environment module.

Some new benzimidazolylalkyl thioureas and thiazolidones as possible anticonvulsants

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