775233-43-7 Usage
Description
Cefotiam Impurity 1, also known as (6R,7R)-3-Hydroxymethyl-7-((2-aminothiazol-4-yl)acetamido)ceph-3-em-4-carboxylic Acid, is a derivative of Cephalothin, a first-generation cephalosporin antibiotic. It exhibits a wide range of antibacterial activity, being effective against both gram-positive and gram-negative bacteria. This impurity is a potential intermediate for the development of antibiotics, playing a significant role in the pharmaceutical industry.
Uses
Used in Pharmaceutical Industry:
Cefotiam Impurity 1 is used as an intermediate in the development of antibiotics for various applications, including the treatment of bacterial infections. Its wide range of antibacterial activity makes it a valuable component in the creation of effective antibiotic medications.
Used in Respiratory Disease Treatment:
Cefotiam Impurity 1 is utilized in the treatment of respiratory diseases caused by gram-positive and gram-negative bacteria. Its effectiveness in combating these bacteria contributes to the improvement of patients' respiratory health.
Used in Neuromuscular Junction Studies:
In addition to its clinical applications, Cefotiam Impurity 1 is also used in research settings, specifically in the study of the neuromuscular junction. This impurity aids in understanding the mechanisms of action and potential therapeutic applications in neuromuscular disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 775233-43-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,7,5,2,3 and 3 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 775233-43:
(8*7)+(7*7)+(6*5)+(5*2)+(4*3)+(3*3)+(2*4)+(1*3)=177
177 % 10 = 7
So 775233-43-7 is a valid CAS Registry Number.
775233-43-7Relevant articles and documents
A new cephalosporin. SCE-963: 7-[2-(2-aminothiazol-4-yl)-acetamido]-3- [[[1-(2-dimethylaminoethyl)-1h-tetrazol-5-yl]-thio]methyl]ceph-3-em-4-carboxylic acid. Chemistry and structure-activity relationships
Numata,Minamida,Yamaoka,Shiraishi,Miyawaki,Akimoto,Naito,Kida
, p. 1262 - 1271 (1978)
The synthesis and the in vitro and in vivo antimicrobial activities of a series of 7-[2-(2-aminothiazol-4-yl)acetamido]cephalosporins (1) having varied 3-substituents, such as methyl, hydroxymethyl, acetoxymethyl, pyridiniomethyl and heterocyclicthiomethyls, are described. The derivates having five membered heterocyclicthiomethyls exhibited strong inhibitory activities against Gram-negative organisms including some strains od Escherichia coli and Proteus morganii which are insensitive to cefazolin and cephaloridine. Pronounced activities were noted with 7-[2-(2-aminothiazol-4-yl)-acetamido]-3-[[[1-(2-dimethylaminoethyl)-1H-tetra zol-5-yl]thio]methyl]ceph-3-em-4-carboxylic acid (1y;SCE-963).
