776-41-0 Usage
Description
Ethyl indole-3-carboxylate is a yellow solid compound that has been isolated from the South China Sea sponge, Xetospongia testudinaria. It is known for its unique chemical properties and various applications across different industries.
Uses
Used in Pharmaceutical Industry:
Ethyl indole-3-carboxylate is used as a reactant for the preparation of indole-based heterocycles, which are essential in the synthesis of indole-based p38 inhibitors and gramines. These compounds play a crucial role in the development of new drugs for various medical applications.
Used in Neuroscience Research:
In the field of neuroscience, ethyl indole-3-carboxylate is used as a glycine receptor ligand. This application aids in the study of the nervous system and the development of treatments for neurological disorders.
Used in Inflammation and Allergy Research:
Ethyl indole-3-carboxylate is also used as an inhibitor of human 5-lipoxygenase, an enzyme involved in the production of leukotrienes, which are associated with inflammation and allergy. This application contributes to the development of anti-inflammatory and anti-allergic drugs.
Used in Antimicrobial Applications:
Furthermore, ethyl indole-3-carboxylate is utilized as an antimicrobial agent, demonstrating its potential in the development of new antibiotics and antifungal agents to combat drug-resistant infections.
Check Digit Verification of cas no
The CAS Registry Mumber 776-41-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 7,7 and 6 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 776-41:
(5*7)+(4*7)+(3*6)+(2*4)+(1*1)=90
90 % 10 = 0
So 776-41-0 is a valid CAS Registry Number.
InChI:InChI=1/C11H11NO2/c1-2-14-11(13)9-7-12-10-6-4-3-5-8(9)10/h3-7,12H,2H2,1H3
776-41-0Relevant articles and documents
Convenient method of synthesizing 3-ethoxycarbonyl indoles
Islam, M. Shahidul,Brennan, Courtney,Wang, Qinwei,Hossain, M. Mahmun
, p. 4675 - 4677 (2006)
We have developed a convenient two-step procedure for the synthesis of 3-ethoxycarbonyl indoles from commercially available materials. The two-step procedure involves the synthesis of 2-aryl-3-hydroxypropenoic acid ester, followed by a catalytic reduction
A general and scalable synthesis of polysubstituted indoles
Diana-Rivero, Raquel,García-Tellado, Fernando,Tejedor, David
, (2021/06/14)
A consecutive 2-step synthesis of N-unprotected polysubstituted indoles bearing an electron-withdrawing group at the C-3 position from readily available nitroarenes is reported. The protocol is based on the [3,3]-sigmatropic rearrangement of N-oxyenamines generated by the DABCO-catalyzed reaction of N-arylhydroxylamines and conjugated terminal alkynes, and delivers indoles endowed with a wide array of substitution patterns and topologies.
Amination/Cyclization Cascade by Acid-Catalyzed Activation of Indolenine for the One-Pot Synthesis of Phaitanthrin E
Abe, Takumi,Yamada, Koji
supporting information, p. 6504 - 6507 (2016/12/23)
We have developed a concise one-pot synthesis of phaitanthrin E derivatives, where simple starting materials undergo an acid-catalyzed intermolecular amination/intramolecular cyclization cascade.