77627-63-5Relevant articles and documents
One pot synthesis using supported reagents system KSCN/SiO 2-RNH3OAc/Al2O3: Synthesis of 2-aminothiazoles and N-allylthioureas
Aoyama, Tadashi,Murata, Sumiko,Arai, Izumi,Araki, Natsumi,Takido, Toshio,Suzuki, Yoshitada,Kodomari, Mitsuo
, p. 3201 - 3213 (2007/10/03)
A simple and efficient method has been developed for the synthesis of 2-aminothiazoles and N-allylthioureas from commercially available materials in one pot by using a supported reagents system, KSCN/SiO2-RNH 3OAc/Al2O3, in which α-halo ketone reacts first KSCN/SiO2 and the product, α-thiocyanatoketone, reacts with RNH3OAc/Al2O3 to give the final product, 2-aminothiazoles, in good yield and allyl bromide reacts with KSCN/SiO 2 and the product, allyl isothiocyanate, reacts with RNH 3OAc/Al2O3 to give N-allylthiourea.
Synthesis of N-(2-Substituted-ethyl)-N'-arylpiperazines and Their Quaternary Salts as Potential Antihookworm Agents
Rastogi, Rashmi,Sharma, Satyavan,Iyer, R. N.
, p. 1003 - 1005 (2007/10/02)
A series of N-(2-substituted-ethyl)-N'-arylpiperazines (4-15) and their quaternary salts (17-21) have been prepared and tested for their antihookworm activity against Nippostrongylus brasiliensis in rats and Nematospiroides dubius in mice.Of the compounds