77629-24-4

Basic information

• Product Name: benzyl cobactin T
• Synonyms: benzyl cobactin T
• CAS NO: 77629-24-4
• Molecular Weight: 320.389
• Mol File: 77629-24-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: benzyl cobactin T(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl cobactin T(77629-24-4)
• EPA Substance Registry System: benzyl cobactin T(77629-24-4)

Safety Data

• Hazardous Substances Data: 77629-24-4(Hazardous Substances Data)

Upstream product

• 300-85-6 D-β-hydroxybutyric acid 
• 77611-42-8 3-Amino-1-benzyloxy-azepan-2-one 
• 77611-39-3 (1-Benzyloxy-2-oxo-azepan-3-yl)-carbamic acid tert-butyl ester 
• 1007123-23-0 (S)-3-amino-1-(benzyloxy)azepan-2-one hydrobromide 
• 625-72-9 (R)-3-hydroxybutyric acid 
• 1007123-22-9 (S)-1-(benzyloxy)-3-(benzyloxycarbonylamino)azepan-2-one 
• 77611-39-3 L-N_α-Boc-α-amino-N-(benzyloxy)caprolactame 
• 77611-42-8 L-α-amino-N-(benzyloxy)caprolactam 

Downstream Products

• 84028-50-2 mycobactin S₂ 
• 1399266-69-3 C₄₆H₇₂N₄O₇*BrH 
• 1399266-72-8 C₅₆H₈₀N₆O₁₀ 
• 1399266-75-1 C₆₁H₈₈N₆O₁₂ 
• 1399266-78-4 C₄₂H₆₈N₆O₁₀ 
• 1399266-81-9 C₅₀H₇₆N₆O₁₄ 
• 1399266-84-2 C₄₇H₇₆N₆O₁₂ 
• 1399266-87-5 C₅₃H₈₂N₆O₁₅ 
• 1399266-90-0 C₄₈H₇₄N₆O₁₃ 
• 1399266-98-8 C₅₇H₈₃N₇O₁₆ 
• 1399266-66-0 C₅₄H₇₈N₄O₉ 
• 84028-62-6 tribenzyl mycobactin S₂ 

Relevant articles and documents

Syntheses of mycobactin analogs as potent and selective inhibitors of Mycobacterium tuberculosis

Three analogs of mycobactin T, the siderophore secreted by Mycobacterium tuberculosis (Mtb) were synthesized and screened for their antibiotic activity against Mtb H37Rv and a broad panel of Gram-positive and Gram-negative bacteria. The synthetic mycobactins were potent (MIC90 0.02-0.88 μM in 7H12 media) and selective Mtb inhibitors, with no inhibitory activity observed against any other of the microorganisms tested. The maleimide-containing analog 40 represents a versatile platform for the development of mycobactin-drug conjugates, as well as other applications.

Mycobactins: Synthesis of (-)-Cobactin T from ε-Hydroxynorleucine

The synthesis of (-)-cobactin T is described, the key step being ring closure between C6 and the hydroxamate N of α-N-(tert-butoxycarbonyl)-ε-hydroxynorleucine O-benzylhydroxamate.