776297-03-1

Basic information

• Product Name: ethyl 2-benzyl-3-(4-chlorophenyl)-3-oxopropanoate
• Synonyms: ethyl 2-benzyl-3-(4-chlorophenyl)-3-oxopropanoate
• CAS NO: 776297-03-1
• Molecular Weight: 316.784
• Mol File: 776297-03-1.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: ethyl 2-benzyl-3-(4-chlorophenyl)-3-oxopropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-benzyl-3-(4-chlorophenyl)-3-oxopropanoate(776297-03-1)
• EPA Substance Registry System: ethyl 2-benzyl-3-(4-chlorophenyl)-3-oxopropanoate(776297-03-1)

Safety Data

• Hazardous Substances Data: 776297-03-1(Hazardous Substances Data)

Upstream product

• 15626-54-7 2-diazo-3-phenyl-propionic acid ethyl ester 
• 104-88-1 4-chlorobenzaldehyde 
• 100-39-0 benzyl bromide 
• 2881-63-2 ethyl (4-chlorobenzoyl)acetate 
• 591-50-4 iodobenzene 
• 147849-98-7 ethyl 2-((4-chlorophenyl)(hydroxy)methyl)acrylate 
• 620-79-1 Ethyl 2-benzylacetoacetate 
• 4231-70-3 p-chlorobenzoyl-1H-1,2,3-benzotriazole 

Downstream Products

• 5739-37-7 4'-chloro-3-phenylpropiophenone 

Relevant articles and documents

Carbocation Lewis Acid TrBF4-Catalyzed 1,2-Hydride Migration: Approaches to (Z)-α,β-Unsaturated Esters and α-Branched β-Ketocarbonyls

Carbocation Lewis acid TrBF4-catalyzed 1,2-hydride migration of α-alkyldiazoacetates themselves or in situ-generated cross-coupling adducts of aldehydes and α-alkyldiazoacetates has been developed, affording (Z)-α,β-unsaturated esters and α-branched β-ketocarbonyls, respectively, in good yields and with high regioselectivities.

Thiourea catalysed reduction of α-keto substituted acrylate compounds using Hantzsch ester as a reducing agent in water

The first method for the reduction of α-keto substituted acrylate compounds by Hantzsch ester in water under the catalysis of thiourea has been developed. The products were isolated in moderate to high yields (38-95%). These products are important intermediates in the synthesis of a series of natural products and other biologically active molecules.

Nájera oxime-derived palladacycles catalyze intermolecular Heck reaction with Morita-Baylis-Hillman adducts. An improved and highly efficient synthesis of α-benzyl-β-ketoesters

An improved and highly efficient synthesis of several α-benzyl-β-ketoesters from Morita-Baylis-Hillman adducts is described. These adducts were used as substrates for an intermolecular Heck reaction catalyzed by a Na?jera oxime-derived palladacycles. These efficient catalytic conditions probed to be very selective providing only the corresponding functionalized β-ketoesters in high yield with no decarboxylation product. It seems that the method herein described is one of the most efficient for the synthesis of α-benzyl-β-ketoesters.