7763-65-7

Basic information

• Product Name: H-HIS-LEU-OH
• Synonyms: (S)-2-((S)-2-aMino-3-(1H-iMidazol-4-yl)propanaMido)-4-Methylpentanoic acid;L-Leucine, L-histidyl-;N-Histidylleucine;-2-Amino-3-(1H-imidazol-4-yl);His-Leu-OH≥ 99% (TLC);L-HISTIDYL-L-LEUCINE;H-HIS-LEU-OH;HIS-LEU
• CAS NO: 7763-65-7
• Molecular Formula: C₁₂H₂₀N₄O₃
• Molecular Weight: 268.31
• Product Categories: Dipeptides;Dipeptides and Tripeptides;Peptides
• Mol File: 7763-65-7.mol
• Article Data: 7

Chemical Properties

• Melting Point: 217-220℃
• Boiling Point: 623 °C at 760 mmHg
• Flash Point: 330.6 °C
• Appearance: /
• Density: 1.249 g/cm³
• Vapor Pressure: 2.21E-16mmHg at 25°C
• Refractive Index: 1.559
• Storage Temp.: −20°C
• CAS DataBase Reference: H-HIS-LEU-OH(CAS DataBase Reference)
• NIST Chemistry Reference: H-HIS-LEU-OH(7763-65-7)
• EPA Substance Registry System: H-HIS-LEU-OH(7763-65-7)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 7763-65-7(Hazardous Substances Data)

Usage

Chemical Properties

White powder

Definition

ChEBI: A dipeptide formed from L-histidine and L-leucine residues.

InChI:InChI=1/C12H20N4O3/c1-7(2)3-10(12(18)19)16-11(17)9(13)4-8-5-14-6-15-8/h5-7,9-10H,3-4,13H2,1-2H3,(H,14,15)(H,16,17)(H,18,19)

Upstream product

• 106654-30-2 N-(1,N^α-bis-benzyloxycarbonyl-histidyl)-leucine methyl ester 
• 122338-83-4 N-(1-benzyl-N^α-benzyloxycarbonyl-L-histidyl)-L-leucine-benzyl ester 
• 2743-60-4 L-Leucine ethyl ester 
• 18428-28-9 N-cyclohexylcarbodiimide 
• 74853-62-6 N^α,N^im-ditritylhistidine 
• 38972-90-6 N-(N^α-benzyloxycarbonyl-histidyl)-leucine 
• 31373-65-6 N-α-hippuryl-L-histidyl-L-leucine 
• 484-42-4 angiotensin I 
• 2666-93-5 (S)-Leu-OMe 
• 64991-62-4 N(α)-t-butoxycarbonyl-N(Im)-diphenyl-4-pyridylmethyl-L-histidine 
• 77422-41-4 (S)-2-{(S)-2-tert-Butoxycarbonylamino-3-[1-(diphenyl-pyridin-4-yl-methyl)-1H-imidazol-4-yl]-propionylamino}-4-methyl-pentanoic acid 
• 77422-47-0 (S)-2-{(S)-2-tert-Butoxycarbonylamino-3-[1-(diphenyl-pyridin-4-yl-methyl)-1H-imidazol-4-yl]-propionylamino}-4-methyl-pentanoic acid methyl ester 
• 41445-69-6 N-benzyloxycarbonyl-L-histidyl azide 
• 30033-84-2 N-(N^α-benzyloxycarbonyl-histidyl)-leucine methyl ester 

Downstream Products

• 31373-65-6 N-α-hippuryl-L-histidyl-L-leucine 
• 1093075-61-6 histidinylleucinato^(2-)-O,N,N-diphenyltin(IV) 

Relevant articles and documents

A study of chimeras constructed with the two domains of angiotensin I-converting enzyme

Angiotensin I-converting enzyme (ACE) is composed of two highly similar domains called the N and C domains, which display some contrasting enzymatic properties. We constructed two ACE chimeras: chimera 1, comprised of the N domain containing the central 60 amino acid residues of the C domain, and chimera 2, comprised of the C domain containing the central 60 amino acid residues of the N domain. Chimeras 1 and 2 displayed K(m) values for Hip-His-Leu and Z-Phe-His-Leu and k(cat) ratios for these two substrates similar to that of the N and C domains, respectively. Thus, the short sequence exchanged between the two domains does not confer the specific properties of that domain for these two substrates but, rather, such specific properties must arise from the sequences surrounding the central region in each domain.

DPP4 INHIBITOR AND PHARMACEUTICAL APPLICATION THEREOF

The present invention provides a Dpp4 inhibitor which comprises a leucine derivative of the following formula (1) or a methionine derivative of the following formula (2): wherein each R1 and R3 represents a hydrogen atom (H) and an L-amino acid residue; R2 represents a hydroxyl group (OH), alkoxy group having 1 to 6 carbon atoms, amino group (NH2), alkylamino group having 1 to 6 carbon atoms, glycine residue, β-alanine residue, L-amino acid (except for proline, alanine and phenylalanine) residue or L-amino-acid amide (except for proline amide, alanine amide and phenylalanine amide) residue; and R4 represents a hydroxyl group (OH), alkoxy group having 1 to 6 carbon atoms, amino group (NH2), alkylamino group having 1 to 6 carbon atoms, glycine residue, β-alanine residue, L-amino acid (except for proline and alanine) residue or L-amino-acid amide (except for proline amide and alanine amide) residue. These derivatives also act as autophagy regulators.

Novel fluorogenic substrates containing bimane system for microdetermination of angiotensin I converting enzyme

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