77635-38-2

Basic information

• Product Name: Ethanone, 1-(3-nitrophenyl)-, phenylhydrazone
• CAS NO: 77635-38-2
• Molecular Formula: C14H13N3O2
• Molecular Weight: 255.276
• Mol File: 77635-38-2.mol
• Article Data: 23

Chemical Properties

• CAS DataBase Reference: Ethanone, 1-(3-nitrophenyl)-, phenylhydrazone(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-(3-nitrophenyl)-, phenylhydrazone(77635-38-2)
• EPA Substance Registry System: Ethanone, 1-(3-nitrophenyl)-, phenylhydrazone(77635-38-2)

Safety Data

• Hazardous Substances Data: 77635-38-2(Hazardous Substances Data)

Upstream product

• 100-63-0 phenylhydrazine 
• 100-19-6 (4-nitrophenyl)ethanone 
• 121-89-1 3-Nitroacetophenone 
• 59-88-1 phenylhydrazine hydrochloride 
• 5340-12-5 1,2-bis(1-(3-nitrophenyl)ethylidene)hydrazine 

Downstream Products

• 380449-93-4 C₂₄H₁₆FN₃O₃ 
• 1431666-25-9 C₂₆H₂₀FN₅O₃ 
• 1431666-32-8 C₃₀H₂₂FN₅O₂ 
• 6127-50-0 2-(3-nitrophenyl)-1H-indole 

Relevant articles and documents

Discovery of New 4-Indolyl Quinazoline Derivatives as Highly Potent and Orally Bioavailable P-Glycoprotein Inhibitors

The major drawbacks of P-glycoprotein (P-gp) inhibitors at the clinical stage make the development of new P-gp inhibitors challenging and desirable. In this study, we reported our structure-activity relationship studies of 4-indolyl quinazoline, which led to the discovery of a highly effective and orally active P-gp inhibitor, YS-370. YS-370 effectively reversed multidrug resistance (MDR) to paclitaxel and colchicine in SW620/AD300 and HEK293T-ABCB1 cells. YS-370 bound directly to P-gp, did not alter expression or subcellular localization of P-gp in SW620/AD300 cells, but increased the intracellular accumulation of paclitaxel. Furthermore, YS-370 stimulated the P-gp ATPase activity and had moderate inhibition against CYP3A4. Significantly, oral administration of YS-370 in combination with paclitaxel achieved much stronger antitumor activity in a xenograft model bearing SW620/Ad300 cells than either drug alone. Taken together, our data demonstrate that YS-370 is a promising P-gp inhibitor capable of overcoming MDR and represents a unique scaffold for the development of new P-gp inhibitors.

Copper catalyzed cyanomethylation reaction of 4-thiazolidinone

An effective copper catalyzed Cross Dehydrogenative Coupling (CDC) reaction of 4-thiazolidinones with acetonitrile has been developed. The described strategy undergoes radical pathway by employing copper, oxidant and easily available acetonitrile as a cya

Imidazole-pyrazole hybrids: Synthesis, characterization and in-vitro bioevaluation against α-glucosidase enzyme with molecular docking studies

Herein, substituted imidazole-pyrazole hybrids (2a-2n) were prepared via a multi component reaction employing pyrazole-4-carbaldehydes (1a-1d), ammonium acetate, benzil and arylamines as reactants. All the new compounds were characterized through their spectral and elemental analyses. Further these compounds were tested against α-glucosidase enzyme. The compounds 2k, 2l and 2n possessed good inhibition potencies, however, compounds 2f (IC50 value: 25.19 ± 0.004 μM) and 2m (IC50 value: 33.62 ± 0.03 μM) were the most effective compounds of the series. Furthermore, molecular docking helped to understand the binding interactions of 2f and 2m with the understudy yeast's α-glucosidase enzyme.