7766-37-2

Basic information

• Product Name: N-(4-methoxyphenyl)acrylamide
• Synonyms: N-(4-methoxyphenyl)acrylamide;Einecs 231-860-7
• CAS NO: 7766-37-2
• Molecular Formula: C₁₀H₁₁NO₂
• Molecular Weight: 177.19984
• EINECS: 231-860-7
• Mol File: 7766-37-2.mol
• Article Data: 30

Chemical Properties

• Boiling Point: 349.6°C at 760 mmHg
• Flash Point: 165.2°C
• Appearance: /
• Density: 1.12g/cm³
• Vapor Pressure: 4.66E-05mmHg at 25°C
• Refractive Index: 1.565
• CAS DataBase Reference: N-(4-methoxyphenyl)acrylamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-methoxyphenyl)acrylamide(7766-37-2)
• EPA Substance Registry System: N-(4-methoxyphenyl)acrylamide(7766-37-2)

Safety Data

• Hazardous Substances Data: 7766-37-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H11NO2/c1-3-10(12)11-8-4-6-9(13-2)7-5-8/h3-7H,1H2,2H3,(H,11,12)

Upstream product

• 116707-97-2 N-(2-bromo-4-methoxyphenyl)acrylamide 
• 340011-43-0 N-(4-methoxyphenyl)-3-(phenylsulfonyl)propanamide 
• 104-94-9 4-methoxy-aniline 
• 598-72-1 2-Bromopropionic acid 
• 814-68-6 acryloyl chloride 
• 19313-87-2 N-(4-methoxyphenyl)-β-chloropropanamide 
• 32338-02-6 2-bromo-4-methoxyaniline 
• 100-17-4 para-methoxynitrobenzene 
• 696-62-8 para-iodoanisole 
• 79-06-1 2-propenamide 
• 73595-45-6 N-(4-Methoxy-phenyl)-3-methylsulfanyl-propionamide 

Downstream Products

• 86523-72-0 N-(4-Methoxy-phenyl)-3-(4-pyridin-2-yl-piperazin-1-yl)-propionamide 
• 108811-79-6 1,4,5,6,7,7-Hexabromo-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid (4-methoxy-phenyl)-amide 
• 340011-48-5 N-allyl N-(4-methoxyphenyl)acrylamide 
• 78450-02-9 N-(4-methoxyphenyl) α,β-unsaturated γ-lactam 
• 177422-34-3 N-(p-methoxyphenyl)-1,2,3,4-tetrahydro-2-ethoxy-6-cyanopyridine 
• 1412410-77-5 (E)-3-(7-methoxy-4-oxo-4H-chromen-3-yl)-N-(4-methoxyphenyl)acrylamide 
• 1639785-80-0 3,6-bis[4-(trifluoromethyl)phenyl]-1,4,2,5-dioxadiazine 

Relevant articles and documents

Synthesis of 4-Trifluoromethylated 1,3-Butadienes via Palladium Catalyzed Heck Reaction

1,3-Butadiene plays a key role in modern synthetic chemistry and biochemistry because it is a key intermediate in the synthesis of many drugs. A new and effective method for the synthesis of 4-trifluoromethylated 1,3-butadiene through the fluorinated Heck reaction catalyzed by Pd(0) is described. Without additives, 1-chloro-3,3,3-trifluoropropene (an inexpensive CF3 structural unit that is harmless to ozone) reacts with enamide to synthesize 4-trifluoromethylated 1,3-butadienes with good yield, high regioselectivity and chemical selectivity, and strong tolerance of substrate functional groups such as alkynes, aldehyde, and ester groups.

Silyl Radical-Mediated Activation of Sulfamoyl Chlorides Enables Direct Access to Aliphatic Sulfonamides from Alkenes

Single electron reduction is more challenging for sulfamoyl chlorides than sulfonyl chlorides. However, sulfamoyl and sulfonyl chlorides can be easily activated by Cl-atom abstraction by a silyl radical with similar rates. This latter mode of activation was therefore selected to access aliphatic sulfonamides, applying a single-step hydrosulfamoylation using inexpensive olefins, tris(trimethylsilyl)silane, and photocatalyst Eosin Y. This late-stage functionalization protocol generates molecules as complex as sulfonamide-containing cyclobutyl-spirooxindoles for direct use in medicinal chemistry.

Rh(i)-Catalyzed regioselective arylcarboxylation of acrylamides with arylboronic acids and CO2

The first Rh(i)-catalyzed regioselective arylcarboxylation of electron-deficient acrylamides with arylboronic acids under atmospheric pressure of CO2 has been developed. A range of acrylamides and arylboronic acids were compatible with this reaction under redox-neutral conditions, leading to a series of malonate derivatives that are versatile building blocks in organic syntheses.