77711-05-8Relevant articles and documents
Cleavage and biotransformation of the centrally acting muscle relaxant chlormezanone
Oelschlaeger,Klinger,Rothley,Seeling,Bockhard,Hofmann,Machts,Riederer,Rackur
, p. 620 - 624 (2007/10/03)
Chlormezanone, a chiral centrally acting muscle relaxant, will be cleaved at its S-C-1 bond by an autoprotolytic process. The optimum of chemical stability exists between pH 2 up to pH 9 with a maximum at pH 7.4. The plasma half life at 37 °C is 76 h. Enzymes do attack the products of cleavage namely 4-chlorobenzaldehyde and 2-carboxyethane-sulfinic acid-N- methyl-amide. The main metabolite in urine is 4-chlorohippuric acid in the range of up to 70% of the oral administered dose to humans. No cytochrome P- 450 is engaged in the cleavage of the S-C-bond.
