77713-52-1

Basic information

• Product Name: bis(2-diethylaminoethyl) 1-(tetrahydro-2-furyl)-3-(1-naphthyl)propane-2,2-dicarboxylate
• CAS NO: 77713-52-1
• Molecular Weight: 526.717
• Mol File: 77713-52-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: bis(2-diethylaminoethyl) 1-(tetrahydro-2-furyl)-3-(1-naphthyl)propane-2,2-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: bis(2-diethylaminoethyl) 1-(tetrahydro-2-furyl)-3-(1-naphthyl)propane-2,2-dicarboxylate(77713-52-1)
• EPA Substance Registry System: bis(2-diethylaminoethyl) 1-(tetrahydro-2-furyl)-3-(1-naphthyl)propane-2,2-dicarboxylate(77713-52-1)

Safety Data

• Hazardous Substances Data: 77713-52-1(Hazardous Substances Data)

Upstream product

• 86-52-2 1-Chloromethylnaphthalene 
• 17448-96-3 ethyl 2-carbethoxy-3-(2-furanyl)propenoate 
• 37136-39-3 diethyl 2-((tetrahydrofuran-2-yl)methyl)malonate 
• 85068-37-7 diethyl 1-(tetrahydro-2-furyl)-3-(1-naphthyl)propane-2,2-dicarboxylate 
• 98-01-1 furfural 
• 97-99-4 Tetrahydrofurfuryl alcohol 
• 1192-30-9 tetrahydrofurfuryl bromide 
• 869-24-9 2-chloro-N,N-diethylethylamine hydrochloride 
• 113527-39-2 1-(tetrahydro-2-furyl)-3-(1-naphthyl)propane-2,2-dicarboxylic acid 

Relevant articles and documents

2-DIETHYLAMINOETHYL ESTERS OF 1,3-DISUBSTITUTED PROPANE-2-CARBOXYLIC ACIDS

Alkaline hydrolysis of diethyl 1-(tetrahydro-2-furyl)-3-(1-naphthyl)propane-2,2-dicarboxylate (IV) gave the crude acid V which was purified via the dipotassium salt and was obtained as the homogenous higher melting crystal form.Its thermic decarboxylation yielded the acid II as a mixture of two racemates (38:62); crystallization led to almost homogenous racemate B (10:90).Reaction of the sodium salt of II with dimethyl sulfate in methanol gave the methyl ester III which afforded by ester exchange with 2-diethylaminoethanol the ester I (mixture of two racemates 34:66). 2-Diethylaminoethyl 1,3-bis(1-naphthyl)propane-2-carboxylate (VII) was synthetized in three steps from diethyl (1-naphthylmethyl)malonate.Ester X was obtained from 1,3-bis(tetrahydro-2-furyl)propane-2-carboxylic acid by treatment with 2-diethylaminoethyl chloride in boiling 2-propanol in the presence of potassium carbonate.The acid V gave similarly the diester VI. 2-Diethylaminoethyl esters I, VI, VII, and X were transformed to the hydrogen oxalates.Pharmacological screening showed for the diester VI hypotensive, spasmolytic, antiarrhythmic, and antitussic activity.