77726-78-4Relevant articles and documents
Real time HR-MAS NMR: Application in reaction optimization, mechanism elucidation and kinetic analysis for heterogeneous reagent catalyzed small molecule chemistry
Roy, Abhijeet Deb,Jayalakshmi,Dasgupta, Somnath,Roy, Raja,Mukhopadhyay, Balaram
, p. 1119 - 1126 (2008)
A novel application of in situ 1H high-resolution magic angle spinning (HR-MAS) NMR technique for real-time monitoring of H2SO 4-silica promoted formation of 2, 2-disubstituted quinozolin-4(3H)-ones is reported. The detailed NMR spectroscopic data led to elucidation of the mechanism, reaction optimization, kinetics and quantitative analysis of the product accurately and efficiently. The translation of the optimized parameters obtained by 1H HR-MAS NMR in the wet laboratory provided similar results. It is proposed that 1H HR-MAS has a potential utility for optimization of various organic transformations in solid supported catalyzed reactions. Copyright
Catalyst-free synthesis of quinazolinones by oxidative cyclization under visible light in the absence of additives
Yang, Jiangnan,Xie, Zongbo,Chen, Zhongsheng,Jin, Liang,Li, Qian,Le, Zhanggao
, p. 1496 - 1501 (2021/05/03)
A general metal-free oxidative cyclization route was developed to synthesize quinazolinones under visible light. A series of substituted 2-aminobenzamides were reacted with aldehydes or ketones to produce the desired quinazolinones in good yields. Most importantly, the reaction did not require excess oxidant or high temperatures.
Selective synthesis of functionalized quinazolinone derivatives via biocatalysis
Gong, Bozhen,Lan, Jin,Le, Zhanggao,Li, Hongxia,Meng, Jia,Xie, Zongbo
, (2020/11/02)
A novel and efficient biocatalyzed methodology for the construction of functionalized quinazolinone derivatives via tandem / hydrolysis / decarboxylation / cyclization and transesterification reactions has been developed that works with a variety of 2-aminobenzamide and β-dicarbonyl compounds. This method requires mild conditions, and has demonstrated high catalytic activity, excellent yields, excellent chemoselectivity, and a broad substrate scope. Additionally, biocatalyzed decarboxylation does not require high temperatures or light activation, giving it a substantial advantage over alternative techniques. Most importantly, it offers a new example for the exploration of simple, convenient, and environmentally friendly synthetic routes utilizing enzymes in organic chemistry.