77791-12-9Relevant articles and documents
Cu-Catalyzed Synthesis of Benzoxazole with Phenol and Cyclic Oxime
Wang, Zheng-Hai,Wang, Dong-Hui
supporting information, p. 782 - 785 (2022/01/20)
A Cu-catalyzed straightforward synthesis of benzoxazoles from free phenols and cyclic oxime esters is reported. The mild reaction conditions tolerate various electron-withdrawing and electron-donating functional groups on both substrates, affording benzoxazoles in moderate to good yields. With this protocol, large-scale syntheses of Ezutromid and Flunoxaprofe in one or two steps are demonstrated. A catalytic mechanism, which includes Cu-catalyzed amination via inner-sphere electron transfer and consequent annulation, is proposed.
Iodine Promoted One-Pot Synthesis of 2-Aryl Benzoxazoles from Amidoximes via Oxidative Cyclization and Ring Contraction
Zhang, Yong,Ji, Min
supporting information, p. 7506 - 7510 (2019/11/28)
A molecular I2-promoted one-pot synthesis of 2-aryl benzoxazoles has been developed by using amidoximes rather than the limited 2-aminophenols or 2-haloamides as substrates. The amidoxime substrates provided unique and efficient strategies for converting readily available aniline and benzaldehyde precursors into valuable chemicals. This transformation proceeded smoothly under transition-metal-free conditions through a sequential oxidative cyclization and ring contraction, and provided a potential route for introducing certain groups at any site of the scaffold.
Organocatalytic oxidative synthesis of C2-functionalized benzoxazoles, naphthoxazoles, benzothiazoles and benzimidazoles
Kaldhi, Dhananjaya,Vodnala, Nagaraju,Gujjarappa, Raghuram,Nayak, Subhashree,Ravichandiran,Gupta, Sreya,Hazra, Chinmoy K.,Malakar, Chandi C.
supporting information, p. 223 - 229 (2019/01/04)
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