778-65-4

Basic information

• Product Name: 1,2,4-Triazolo[4,3-a]pyridine, 3-phenyl-
• Synonyms: 1,2,4-Triazolo[4,3-a]pyridine, 3-phenyl-;3-Phenyl-1,2,4-triazolo[4,3-a]pyridine
• CAS NO: 778-65-4
• Molecular Formula: C₁₂H₉N₃
• Molecular Weight: 195.22
• Mol File: 778-65-4.mol
• Article Data: 32

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.21g/cm³
• Refractive Index: 1.674
• PKA: 2.93±0.50(Predicted)
• CAS DataBase Reference: 1,2,4-Triazolo[4,3-a]pyridine, 3-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,4-Triazolo[4,3-a]pyridine, 3-phenyl-(778-65-4)
• EPA Substance Registry System: 1,2,4-Triazolo[4,3-a]pyridine, 3-phenyl-(778-65-4)

Safety Data

• Hazardous Substances Data: 778-65-4(Hazardous Substances Data)

Usage

Class

Triazolopyridine compounds

Structural feature

Phenyl group attached at the 3-position of the pyridine ring

Field of application

Medicinal chemistry

Potential therapeutic applications

Exhibits biological activity against certain enzymes and receptors

Significance

Promising candidate for the development of new pharmaceutical drugs

Research interest

Unique structure and properties make it an interesting target for further research in organic synthesis and chemical biology

InChI:InChI=1/C12H9N3/c1-2-6-10(7-3-1)12-14-13-11-8-4-5-9-15(11)12/h1-9H

Upstream product

• 21945-40-4 2-[(2E)-2-benzylidenehydrazinyl]pyridine 
• 41214-53-3 N′-(pyrid-2-yl)benzohydrazide 
• 110-86-1 pyridine 
• 75-05-8 acetonitrile 
• 4930-98-7 pyrid-2-ylhydrazine 
• 65-85-0 benzoic acid 
• 59635-52-8 N-(phenylsulfonyl)benzohydrazonoyl chloride 
• 100-52-7 benzaldehyde 
• 98-88-4 benzoyl chloride 
• 2719-73-5 2-(2-benzylidenehydrazinyl)pyridine 
• 109-09-1 2-chloropyridine 
• 5333-86-8 ethyl benzimidate hydrochloride 
• 62437-99-4 2-hydrazinylpyridine dihydrochloride 
• 825-60-5 benzimidic acid ethyl ester 

Downstream Products

• 89569-61-9 3-phenyl-5,6,7,8-tetrahydro-1,2,4-triazolo<4,3-a>pyridine 

Relevant articles and documents

TBAI/TBHP-Catalyzed Synthesis of [1,2,4]Triazolo[4,3-a]pyridines and 3,5-Diaryl-1,2,4-oxadiazoles via Oxidative Cleavage of C=C Double Bond

Abstract: A simple and efficient protocol has been described for the synthesis of [1,2,4]triazolo[4,3-a]pyri-dines and 3,5-disubstituted-1,2,4-oxadiazoles by reacting 2-hydrazinylpyridine and benzamidoximes, respec-tively, with styrenes via TBAI/TBHP-mediated oxidative cleavage of C=C bond under ligand- and metal-free conditions.

A general strategy for selective detection of hypochlorous acid based on triazolopyridine formation

Triazolopyridines are an important kind of fused-ring compounds. A HOCl-promoted triazolopyridine formation strategy is reported here for the first time in which hypochlorous acid (HOCl) mildly and efficiently promotes the formation of 1,2,4-triazolo[4,3-a]pyridines NT1-NT6 from various 2-pyridylhydrazones N1-N6. N6, a rhodol-pyridylhydrazone hybrid, was developed into a fluorescent probe for the selective detection of HOCl, and successfully applied to probe endogenous HOCl in living cells and zebrafish in situ and in real time. The present intramolecular cyclization reaction is selective and atom-economical, thereby not only providing an important approach for the convenient synthesis of triazolopyridines, but also offering a general strategy for sensitive, selective and biocompatible detection of endogenous HOCl in complex biosystems.

Method for preparing 3-phenyl-[1,2,4] triazole [4,3-a] pyridine compound without metal catalysis

The invention discloses a method for preparing a 3-phenyl-[1,2,4] triazole [4,3-a] pyridine compound without metal catalysis. The method comprises the following steps: enabling a pyridine compound, sodium azide and a benzaldehyde compound to react suffici