7782-51-6

Basic information

• Product Name: (2R)-2-acetamido-3-phenyl-propionic acid
• Synonyms: (2R)-2-acetamido-3-phenylpropanoic acid;(2R)-2-acetamido-3-phenyl-propanoic acid;(2R)-2-acetamido-3-phenyl-propionic acid
• CAS NO: 7782-51-6
• Molecular Formula: C₁₁H₁₃NO₃
• Molecular Weight: 207.22582
• Mol File: 7782-51-6.mol
• Article Data: 19

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2R)-2-acetamido-3-phenyl-propionic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2R)-2-acetamido-3-phenyl-propionic acid(7782-51-6)
• EPA Substance Registry System: (2R)-2-acetamido-3-phenyl-propionic acid(7782-51-6)

Safety Data

• Hazardous Substances Data: 7782-51-6(Hazardous Substances Data)

Usage

Description

(2R)-2-acetamido-3-phenyl-propionic acid, also known as flurbiprofen, is a non-steroidal anti-inflammatory drug (NSAID) that possesses analgesic and anti-inflammatory properties. It is a member of the propionic acid class of NSAIDs and is primarily used for the treatment of pain, inflammation, and swelling related to conditions such as arthritis and menstrual cramps. The mechanism of action involves the inhibition of prostaglandin production, which are molecules that play a role in pain and inflammation within the body.

Uses

Used in Pharmaceutical Industry:
(2R)-2-acetamido-3-phenyl-propionic acid is used as an analgesic and anti-inflammatory agent for the treatment of pain and inflammation associated with various conditions such as arthritis and menstrual cramps. It is effective in reducing swelling and providing relief from discomfort caused by these conditions.
Used in Pain Management:
(2R)-2-acetamido-3-phenyl-propionic acid is used as a pain management tool for acute pain conditions. It is available in various forms, including tablets, capsules, and topical gels, allowing for flexible administration and targeted relief.
However, it is important to note that flurbiprofen, like other NSAIDs, may cause side effects such as stomach irritation, ulcers, and kidney problems. Therefore, it should be used with caution, particularly in individuals with a history of these conditions or other risk factors.

Upstream product

• 55065-02-6 N-acetamido cinnamic acid 
• 55065-02-6 2-(N-acetylamino)cinnamic acid 
• 52386-78-4 N-acetyl dehydrophenylalanine methyl ester 
• 2901-75-9 (R,S)-N-acetyl phenylalanine 
• 14009-95-1 p-nitrophenyl N-acetyl-D-phenylalaninate 

Downstream Products

• 16225-10-8 2-Acetylamino-3-phenyl-propionyl chloride 
• 3618-96-0 Methyl ester of (+)-N-acetylphenylalanine 

Relevant articles and documents

RHODIUM CATALYST AND METHOD FOR MANUFACTURING OPTICALLY ACTIVE COMPOUND USING THE SAME

PROBLEM TO BE SOLVED: To provide a new rhodium complex stable in the air, easy in handling and using an inexpensive optically active H-phosphinate HP(O)R(OR') as a ligand, and a method for asymmetrically hydrogenating olefins efficiently using the same. SOLUTION: The rhodium complex compound has a structure represented by the following general formula (I). (Where in the formula (I), R1 and R2 are carbon substituents which may be the same or different, and two olefins coordinated in Rh may combine with each other as shown by a dotted line to form a ring structure.) COPYRIGHT: (C)2015,JPOandINPIT

Facile synthesis of chiral diphosphine-containing multiple dendrimeric catalysts for enantioselective hydrogenation

A new kind of chiral diphosphine PyrPhos-functionalized codendrimers have been synthesized via a liquid-phase strategy in high yields. The resulting dendrimeric PyrPhos ligands were purified by a simple solvent precipitation without the need for chromatographic separation, and well characterized by 1H, 13C and 31P NMR, MALDI-TOF mass spectroscopy as well as elemental analysis. Their rhodium complexes were applied to the asymmetric hydrogenation of α-acetamido cinnamic acids. Excellent enantioselectivities were achieved, which are comparable to those with the corresponding small molecular catalysts. In addition, these codendrimeric catalysts showed better catalytic performance than the dendrimeric catalysts with Rh(PyrPhos) sites located in the focal point of poly(aryl ether) dendrons or in the periphery of poly(propyleneimine) dendrimers.

NEW ORTHO-FUNCTIONALIZED P-CHIRAL ARYLPHOSPHINES AND DERIVATIVES: THEIR PREPARATION AND USE IN ASYMMETRIC CATALYSIS

The invention relates to novel organo phosphorus P-chiral optically active compounds of formula (I) having a hydroxyl, mercapto, amino, carboxyl, sulfonyl group on aryl near a phosphorus atom, to the preparation and the use thereof in then asymmetrical catalysis of unsaturated compounds. Novel acylphosphine optically pure ligands embodied in the form of transition metal complexes exhibit an increased activity and enantloselectivity, in particular in asymmetrical hydrogenation, in comparison with the same type Uganda such as DiPAMP.