778581-67-2

Basic information

• Product Name: 2-phenyl-5-[4-(trifluoromethyl)phenyl]-1,3-oxazole
• Synonyms: 2-phenyl-5-[4-(trifluoromethyl)phenyl]-1,3-oxazole
• CAS NO: 778581-67-2
• Molecular Weight: 289.257
• Mol File: 778581-67-2.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 2-phenyl-5-[4-(trifluoromethyl)phenyl]-1,3-oxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-phenyl-5-[4-(trifluoromethyl)phenyl]-1,3-oxazole(778581-67-2)
• EPA Substance Registry System: 2-phenyl-5-[4-(trifluoromethyl)phenyl]-1,3-oxazole(778581-67-2)

Safety Data

• Hazardous Substances Data: 778581-67-2(Hazardous Substances Data)

Upstream product

• 1194627-95-6 2-nitro-1-(4-(trifluoromethyl)phenyl)ethan-1-one 
• 707-07-3 orthobenzoic acid trimethyl ester 
• 2996-92-1 phenyl trimethylsiloxane 
• 87150-14-9 5-(4-(trifluoromethyl)phenyl)oxazole 
• 1551606-21-3 (E)-3-(p-tolyl)-1-(4-(trifluoromethyl)phenyl)prop-2-en-1-one 
• 100-46-9 benzylamine 
• 16156-59-5 phenyl methanesulfonate 
• 4920-92-7 pivalic acid phenyl ester 
• 59722-32-6 (3-hydroxyphenyl)methanesulfonate 
• 383-53-9 2-bromo-1-[4-(trifluoromethyl)phenyl]ethanone 
• 709-63-7 1-(4-trifluoromethylphenyl)ethanone 
• 2835-06-5 phenylglycin 
• 339-58-2 2-amino-1-[4-(trifluoromethyl)phenyl]-1-ethanone hydrogen chloride 
• 1299491-27-2 2-(N-benzoylamino)-1-[4-(trifluoromethyl)phenyl]-1-ethanone 

Downstream Products

• 1299491-15-8 (R)-N-[2-hydroxy-2-{4-(trifluoromethyl)phenyl}ethyl]benzamide 
• 1299491-31-8 C₂₅H₂₂F₃NO₄ 
• 1299491-35-2 C₂₅H₂₂F₃NO₄ 
• 1299491-08-9 (R)-2-phenyl-5-[4-(trifluoromethyl)phenyl]oxazoline 
• 1260140-57-5 2-(1,2,3,4,5,6,7,8-octaphenylanthracen-9-yl)-5-(4-trifluoromethylphenyl)oxazole 

Relevant articles and documents

Nickel-catalyzed C?H arylation of benzoxazoles and oxazoles: Benchmarking the influence of electronic, steric and leaving group variations in phenolic electrophiles

Electronic, steric and leaving group effects for Ni-catalyzed direct arylations using C?O electrophiles were benchmarked. The scope of arylations with pivalates was general with respect to both the electronics on the electrophile and the azoles. Furthermore, the arylation of azoles with tosylates, mesylates and carbamates with varying electronics was explored, and showed electronic trends similar to those of the pivalate reactions. Finally, the relative rate of arylation of 5-methyl benzoxazole with two electronically-similar electrophiles bearing different leaving groups was established. The results from these studies implicate the following order of relative reactivity: mesylates>pivalates>carbamates.

Metal-Free sp3 C-H Functionalization: PABS/I2-Promoted Synthesis of Polysubstituted Oxazole Derivatives from Arylethanones and 2-Amino-2-alkyl/arylacetic Acid

A nonmetal-catalyzed process for the synthesis of polysubstituted oxazoles from inexpensive and readily available α-amino acids and methyl ketones is established. This reaction is proposed to achieve oxidative cleavage of C(sp3)-H bonds, followed by decarboxylation and annulation. The mild reaction conditions employed in both cases enable the tolerance of a wide range of functional groups as well as high reaction efficiency.

Catalytic asymmetric hydrogenation of N-Boc-imidazoles and oxazoles

Substituted imidazoles and oxazoles were respectively hydrogenated into the corresponding chiral imidazolines and oxazolines (up to 99% ee). The highly enantioselective hydrogenation was achieved by using the chiral ruthenium catalyst, which is generated