778603-79-5Relevant articles and documents
Novel purine nitrile derived inhibitors of the cysteine protease cathepsin K
Altmann, Eva,Cowan-Jacob, Sandra W.,Missbach, Martin
, p. 5833 - 5836 (2007/10/03)
Starting from the high-throughput screening hit 1a, novel cathepsin K inhibitors have been developed based on a purine scaffold. High-resolution X-ray structures of several derivatives have revealed the binding mode of these unique cysteine protease inhib