778623-19-1

Basic information

• Product Name: 3-methyl-benzoic acid-(2-hydroxy-ethylamide)
• Synonyms: 3-methyl-benzoic acid-(2-hydroxy-ethylamide)
• CAS NO: 778623-19-1
• Molecular Weight: 179.219
• Mol File: 778623-19-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 3-methyl-benzoic acid-(2-hydroxy-ethylamide)(CAS DataBase Reference)
• NIST Chemistry Reference: 3-methyl-benzoic acid-(2-hydroxy-ethylamide)(778623-19-1)
• EPA Substance Registry System: 3-methyl-benzoic acid-(2-hydroxy-ethylamide)(778623-19-1)

Safety Data

• Hazardous Substances Data: 778623-19-1(Hazardous Substances Data)

Upstream product

• 120-33-2 ethyl 3-methylbenzoate 
• 141-43-5 ethanolamine 
• 99-36-5 1-methoxycarbonyl-3-methylbenzene 
• 1711-06-4 3-Methylbenzoyl chloride 
• 99-04-7 m-Toluic acid 
• 1644630-65-8 C₁₄H₁₀ClNO₄ 

Downstream Products

• 43221-63-2 2-(3-methylphenyl)-4,5-dihydro-oxazole 

Relevant articles and documents

Oxazolinyl-Assisted Ru(II)-Catalyzed C-H Allylation with Allyl Alcohols and Synthesis of 4-Methyleneisochroman-1-ones

We report herein a ruthenium-catalyzed, oxazoline-directed strategy for C-H allylation of aryl oxazolines using allylic alcohols as the coupling partner. The present transformation unravels the unusual reactivity of allylic alcohols in the synthesis of 4-

The α-effect in hydrazinolysis of 4-chloro-2-nitrophenyl x-substituted-benzoates: Effect of substituent x on reaction mechanism and the α-effect

Second-order rate constants (kN) have been measured spectrophotometrically for the reaction of 4-chloro-2- nitrophenyl X-substituted-benzoates (6a-6h) with a series of primary amines including hydrazine in 80 mol % H2O/20 mol % DMSO at 25.0°C. The Bronsted-type plot for the reaction of 4-chloro-2-nitrophenyl benzoate (6d) is linear with βnuc = 0.74 when hydrazine is excluded from the correlation. Such a linear Bronsted-type plot is typical for reactions reported previously to proceed through a stepwise mechanism in which expulsion of the leaving group occurs in the rate-determining step (RDS). The Hammett plots for the reactions of 6a-6h with hydrazine and glycylglycine are nonlinear. In contrast, the Yukawa-Tsuno plots exhibit excellent linear correlations with ?X = 1.29-1.45 and r = 0.53-0.56, indicating that the nonlinear Hammett plots are not due to a change in RDS but are caused by resonance stabilization of the substrates possessing an electron-donating group (EDG). Hydrazine is ca. 47-93 times more reactive than similarly basic glycylglycine toward 6a-6h (e.g., the α-effect). The α-effect increases as the substituent X in the benzoyl moiety becomes a stronger electronwithdrawing group (EWG), indicating that destabilization of the ground state (GS) of hydrazine through the repulsion between the nonbonding electron pairs on the two N atoms is not solely responsible for the substituent-dependent α-effect. Stabilization of transition state (TS) through five-membered cyclic TSs, which would increase the electrophilicity of the reaction center or the nucleofugality of the leaving group, contributes to the α-effect observed in this study.