77875-91-3

Basic information

• Product Name: 5-ethynyltrimethylsilyl-3',5'-di-O-p-toluyl-2'-deoxyuridine
• Synonyms: 5-ethynyltrimethylsilyl-3',5'-di-O-p-toluyl-2'-deoxyuridine
• CAS NO: 77875-91-3
• Molecular Weight: 560.679
• Mol File: 77875-91-3.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 5-ethynyltrimethylsilyl-3',5'-di-O-p-toluyl-2'-deoxyuridine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-ethynyltrimethylsilyl-3',5'-di-O-p-toluyl-2'-deoxyuridine(77875-91-3)
• EPA Substance Registry System: 5-ethynyltrimethylsilyl-3',5'-di-O-p-toluyl-2'-deoxyuridine(77875-91-3)

Safety Data

• Hazardous Substances Data: 77875-91-3(Hazardous Substances Data)

Upstream product

• 31356-86-2 1-[2-deoxy-3,5-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl]-5-iodouracil 
• 1066-54-2 trimethylsilylacetylene 

Downstream Products

• 15176-29-1 edoxudine 
• 61135-33-9 2'-deoxy-5-ethynyluridine 
• 69075-43-0 5-Ethynyl-3',5'-di-O-p-toluyl-2'-deoxyuridine 

Relevant articles and documents

Synthesis of tricarbonyl rhenium and technetium complexes of a 5′-carboxamide 5-ethyl-2′-deoxyuridine for selective inhibition of herpes simplex virus thymidine kinase 1

Herpes simplex virus thymidine kinase type 1 (HSV1-TK) is frequently used as reporter protein in gene therapy. Our aim is to produce single photon emitting reporter probe based on technetium-99m. The synthesis of organometallic technetium and rhenium comp

Antiviral compounds

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Nucleic Acid Related Compounds. 39. Efficient Conversion of 5-Iodo to 5-Alkynyl and Derived 5-Substituted Uracil Bases and Nuleosides

Coupling of terminal alkynes with 5-iodo-1-methyl-uracil and 5-iodouracil nucleosides (protected as their p-toluyl esters) proceeded in high yields in the presence of bis(triphenylphosphine)palladium(II) chloride and copper(I)iodide in warm triethylamine.Several of the subsequently deprotected 5-alkynyl-2'-deoxyuridines, including the parent 5-ethynyl-2'-deoxyuridine, had antiviral activity, and their 5'-monophosphates inhibited thymidylate synthetase.Hydrogenation of the 5-alkynyl side chain can be controlled to give (Z)-5-alkenyl- or the saturated 5-alkyl-2'-deoxyuridines.This provides a stereocontrolled route to the known 5-ethyl-and 5-n-hexyl-2'-deoxyuridines as well as (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU).Hydration of the triple bond gave the corresponding uracil-5-alkanone products in favorable cases.