779-71-5

Basic information

• Product Name: 2-CHLORO-5-TRIFLUOROMETHYL-BENZENESULFONAMIDE
• Synonyms: 2-CHLORO-5-TRIFLUOROMETHYL-BENZENESULFONAMIDE;BUTTPARK 83\07-14;2-Chloro-5-(trifluoromethyl)benzene-1-sulfonamide
• CAS NO: 779-71-5
• Molecular Formula: C₇H₅ClF₃NO₂S
• Molecular Weight: 259.63
• Mol File: 779-71-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 347.1°C at 760 mmHg
• Flash Point: 163.7°C
• Appearance: /
• Density: 1.584g/cm³
• Vapor Pressure: 5.52E-05mmHg at 25°C
• Refractive Index: 1.51
• CAS DataBase Reference: 2-CHLORO-5-TRIFLUOROMETHYL-BENZENESULFONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-5-TRIFLUOROMETHYL-BENZENESULFONAMIDE(779-71-5)
• EPA Substance Registry System: 2-CHLORO-5-TRIFLUOROMETHYL-BENZENESULFONAMIDE(779-71-5)

Safety Data

• Hazardous Substances Data: 779-71-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C7H5ClF3NO2S/c8-5-2-1-4(7(9,10)11)3-6(5)15(12,13)14/h1-3H,(H2,12,13,14)

Upstream product

• 54090-08-3 2-chloro-5-trifluoromethyl-benzenesulfonyl chloride 
• 121-50-6 3-amino-4-chlorobenzotrifluoride 
• 98-56-6 4-chlorobenzotrifluoride 
• 121-17-5 2-chloro-3-nitro-5-trifluoromethylbenzene 

Downstream Products

• 1698-38-0 2-benzylamino-5-trifluoromethylbenzenesulfonamide 
• 201224-78-4 2-amino-5-(trifluoromethyl)benzenesulfonamide 
• 1429321-53-8 C₁₄H₉F₃N₂O₂S₂ 
• 1429321-54-9 C₁₆H₁₃F₃N₂O₂S₂ 
• 64903-10-2 1-(2-chloro-5-trifluoromethylphenylsulfonyl)-3-(4-methoxy-6-methyl-1,3,5-triazin-2-yl)urea 
• 1254307-79-3 C₁₅H₇Cl₃F₃N₃O₃S 
• 1254308-11-6 C₁₅H₇Br₂ClF₃N₃O₃S 
• 1254308-88-7 C₁₆H₇ClF₇N₃O₃S 
• 1254309-42-6 C₁₇H₁₀ClF₆N₃O₃S 

Relevant articles and documents

Research on controllable degradation of sulfonylurea herbicides

In order to seek ecologically safer and environmentally benign sulfonylurea herbicides (SU), insight into the structure/bioassay/soil degradation tri-factor relationship was first established. With the introduction of various groups (alkyl, nitro, halogen, cyano etc.) at the 5th position of its benzene ring, structural derivatives of chlorsulfuron were designed, synthesized, and evaluated for their herbicidal activity. The structures of the title compounds were confirmed by infrared spectroscopy, ultraviolet spectroscopy, 1H and 13C NMR, mass spectrometry, elemental analysis and X-ray diffraction. Bioassay results confirmed that most derivatives retained their superior herbicidal activities in comparison with chlorsulfuron. After investigating the soil degradation behavior of each molecule under set conditions, it was found that structures with electron-withdrawing substituents at the 5th position of the benzene ring retained their long degradation half-lives, yet the introduction of electron-donating substituents accelerated the degradation rate. These results will provide a valuable clue to further explore the potential controllable degradation of SU and other herbicides, and to discover novel herbicides that are favorable for environmentally and ecologically sustainable development.

Benzo- and azabenzodithiazole compounds

The present invention provides compounds of formula I or a pharmaceutically acceptable salt, solvate, prodrug or isomer thereof and compounds of the formula or a pharmaceutically acceptable salt, solvate, prodrug or isomer thereof. The compounds of the invention inhibit tyrosine kinase activity of growth factor receptors such as HER1, HER2 and HER4 thereby making them useful as antiproliferative agents. The compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.

Synthesis and biological evaluation of 4-chloro-3,5- dinitrobenzotrifluoride analogues as antileishmanial agents

Desnitro analogues of 4-chloro-3,5-dinitrobenzotrifluoride (chloralin) (2), an in vitro microtubule inhibitor of several Leishmania species, have been synthesized from 2-halo-5-(trifluoromethyl)benzenesulfonyl chlorides 4 and 5. The analogues exhibited mo