779323-43-2 Usage
Description
(1R,2S,4S,5S)-4-[2-IODO-6-(METHYLAMINO)-9H-PURIN-9-YL]-2-(PHOSPHONOOXY)BICYCLO[3.1.0]HEXANE-1-METHANOL DIHYDROGEN PHOSPHATE ESTER TETRAAMMONIUM SALT, also known as MRS 2500 tetraammonium salt, is a chemical compound with a complex structure derived from the bicyclic hexane family. It is characterized by its unique stereochemistry and functional groups, which contribute to its biological activity and potential applications in various fields.
Uses
Used in Pharmaceutical Industry:
MRS 2500 tetraammonium salt is used as a highly potent and selective antagonist for the platelet P2Y1 receptor. Its application is primarily focused on inhibiting ADP-induced aggregation of human platelets, which can be beneficial in the treatment and management of various blood clotting disorders and cardiovascular diseases.
Used in Research and Development:
In addition to its pharmaceutical applications, MRS 2500 tetraammonium salt can also be utilized in research and development settings. It can serve as a valuable tool for studying the role of the P2Y1 receptor in platelet function and related physiological processes. This may lead to a better understanding of the underlying mechanisms involved in blood clotting and the development of novel therapeutic strategies for related conditions.
Used in Drug Delivery Systems:
Similar to gallotannin, MRS 2500 tetraammonium salt could potentially be incorporated into drug delivery systems to enhance its bioavailability and therapeutic outcomes. By employing various organic and metallic nanoparticles as carriers, the compound's delivery, efficacy, and targeting capabilities could be improved, allowing for more effective treatment of conditions related to platelet aggregation and blood clotting.
Biological Activity
Highly potent and selective antagonist of the platelet P2Y 1 receptor (K i = 0.78 nM). Inhibits ADP-induced aggregation of human platelets with an IC 50 value of 0.95 nM. Prevents thrombus formation in vivo .
Check Digit Verification of cas no
The CAS Registry Mumber 779323-43-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,7,9,3,2 and 3 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 779323-43:
(8*7)+(7*7)+(6*9)+(5*3)+(4*2)+(3*3)+(2*4)+(1*3)=202
202 % 10 = 2
So 779323-43-2 is a valid CAS Registry Number.
779323-43-2Relevant articles and documents
Antiaggregatory activity in human platelets of potent antagonists of the P2Y1 receptor
Cattaneo, Marco,Lecchi, Anna,Ohno, Michihiro,Joshi, Bhalchandra V.,Besada, Pedro,Tchilibon, Susanna,Lombardi, Rossana,Bischofberger, Norbert,Harden, T. Kendall,Jacobson, Kenneth A.
, p. 1995 - 2002 (2007/10/03)
Activation of the P2Y1 nucleotide receptor in platelets by ADP causes changes in shape and aggregation, mediated by activation of phospholipase C (PLC). Recently, MRS2500 (2-iodo-N6-methyl-(N)-methanocarba- 2′-deoxyadenosine-3′,5′-bi
