77948-59-5Relevant articles and documents
Preparation of methylfuro[3,4-b] [1,4]benzodioxinones as intermediates for the synthesis of substituted polycyclic systems. Importance of the acid used as catalyst
Bozzo, Consol,Pujol, M. Dolors
, p. 11843 - 11852 (1999)
The lactones 10 and 11 were conveniently prepared in excellent yield by reaction of the corresponding γ-hydroxy amides 6, 7 and 8 in the presence of propionic acid in catalytic amounts. By increasing the ratio of propionic acid used, under the same reaction conditions, the hydroxy amide 6 reacted to give a mixture of ketoamides 13 (cis/trans).
Enantioselective Access to Chiral 2-Substituted 2,3-Dihydrobenzo[1,4]dioxane Derivatives through Rh-Catalyzed Asymmetric Hydrogenation
Yin, Xuguang,Huang, Yi,Chen, Ziyi,Hu, Yang,Tao, Lin,Zhao, Qingyang,Dong, Xiu-Qin,Zhang, Xumu
supporting information, p. 4173 - 4177 (2018/07/29)
Rh-catalyzed asymmetric hydrogenation of various benzo[b][1,4]dioxine derivatives was successfully developed to prepare chiral 2-substituted 2,3-dihydrobenzo[1,4]dioxane derivatives using ZhaoPhos and N-methylation of ZhaoPhos ligands with high yields and excellent enantioselectivities (up to 99% yield, >99% enantiomeric excess (ee), turnover number (TON) = 24 000). Moreover, this asymmetric hydrogenation methodology, as the key step with up to 10 000 TON, was successfully applied to develop highly efficient synthetic routes for the construction of some important biologically active molecules, such as MKC-242, WB4101, BSF-190555, and (R)-doxazosin·HCl.
2-Benzodioxinylaminoethanols: A New Class of β-Adrenergic Blocking and Antihypertensive Agents
Lalloz, Lucien,Loppinet, Vincent,Coudert, Gerard,Guillaumet, Gerald,Loubinoux, Bernard,et al.
, p. 994 - 998 (2007/10/02)
Various 2-benzodioxinylaminoethanol derivatives were synthesized and investigated for β-adrenergic blocking activity.Most compounds demonstrated a β-blocking activity of a competitive type when evaluated in guinea pig atrial and tracheal preparations.Thre
