77970-53-7

Basic information

• Product Name: Ethanone, 2-(ethylsulfonyl)-1-phenyl-
• Synonyms: 2-ethylsulphonylacetophenone;2-ethanesulfonyl-1-phenyl-ethanone;2-Aethansulfonyl-1-phenyl-aethanon
• CAS NO: 77970-53-7
• Molecular Formula: C10H12O3S
• Molecular Weight: 212.269
• Mol File: 77970-53-7.mol
• Article Data: 22

Chemical Properties

• CAS DataBase Reference: Ethanone, 2-(ethylsulfonyl)-1-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 2-(ethylsulfonyl)-1-phenyl-(77970-53-7)
• EPA Substance Registry System: Ethanone, 2-(ethylsulfonyl)-1-phenyl-(77970-53-7)

Safety Data

• Hazardous Substances Data: 77970-53-7(Hazardous Substances Data)

Upstream product

• 536-74-3 phenylacetylene 
• 40721-68-4 N-morpholino-1-phenylethan-1-imine 
• 20035-08-9 sodium ethanesulfinate 
• 98-86-2 acetophenone 
• 594-44-5 Ethanesulfonyl chloride 
• 16717-64-9 1-azidostyrene 
• 37984-88-6 ethanesulfonic acid hydrazide 
• 1889-59-4 ethyl vinyl sulfone 
• 70-11-1 α-bromoacetophenone 
• 100-42-5 styrene 
• 13735-81-4 1-styrenyloxytrimethylsilane 
• 19433-17-1 acetophenone O-acetyloxime 
• 2206-94-2 1-acetoxy-1-phenylethene 
• 93-91-4 1-phenylbutan-1,3-dione 

Relevant articles and documents

Method for preparing beta-carbonyl sulfone compound by using half-sandwich iridium complex

The invention relates to a method for preparing a beta-carbonyl sulfone compound by using a half-sandwich iridium complex, which comprises the following step: in the presence of alkali, by taking acetophenone and sulfonyl chloride as raw materials and taking the half-sandwich iridium complex containing an o-carboborylbenzoxazole structure as a catalyst, conducting reacting at room temperature to prepare the beta-carbonyl sulfone compound. Compared with the prior art, the method has the advantages that the half-sandwich iridium complex containing the o-carboborylbenzoxazole structure is used as the catalyst, acetophenone and sulfonyl chloride are efficiently catalyzed to react under the room temperature condition to synthesize the beta-carbonyl sulfone compound, the product yield is high, the reaction condition is mild, the substrate is cheap and easy to obtain, and the catalytic efficiency is high.

A glucose oxidase-hemoglobin system for efficient oxysulfonylation of alkenes/alkynes in water

Background: β-ketosulfones are important bioactive compounds that have been extensively studied in organic chemistry. In this work, a green and efficient process for the synthesis of β-ketosulfones from alkenes (1) or alkynes (3) with sodium benzenesulfinate (2) was developed. Results: Under optimal conditions (alkenes (0.5 mmol) or alkynes (0.5 mmol), sodium benzenesulfinate (0.5 mmol), water (2 mL), hemoproteins (heme concentration: 0.06 mol%), GOX (42 U/ml), room temperature, 2 h), high yields of β-ketosulfones could be obtained when HgbRb (hemoglobin from rabbit blood) and GOX (glucose oxidase from Aspergillus niger) was used as the catalyst. Conclusion: This enzymatic method demonstrates the great potential for the synthesis of β-ketosulfones and extends the application of dual protein systems in organic synthesis.

Dioxygen-Triggered Oxosulfonylation/Sulfonylation of Terminal Olefins toward β-Keto Sulfones/Sulfones

A dioxygen-triggered oxosulfonylation/sulfonylation of unactivated olefins to achieve β-keto sulfones/sulfones has been developed. Interestingly, pluralistic mechanisms were found when different types of compounds were applied as substrates, and different products were achieved. The reaction is carried out with a high atomic efficiency in the absence of a metal and a catalyst at room temperature under an air atmosphere. Importantly, as a proof-of-concept, a bioactive molecule was synthesized on a gram-scale level using this method.