77988-86-4Relevant articles and documents
The mechanism of the Bischler-Napieralski Reaction
Nagubandi, Sreeramulu,Fodor, G.
, p. 1457 - 1463 (2007/10/02)
The Bischler-Napieralski dihydroisoquinoline synthesis was proven to occur via imidoyl chlorides and the corresponding nitrilium salt.Two-step process required much milder conditions (20 degC - 50 degC) compared to drastic classical conditions of refluxing at 100 degC - 200 degC.The Bischler-Napieralski reaction is shown to share a common intermediate with two other well-known reactions: the von Braun and the Ritter reactions