77995-07-4

Basic information

• Product Name: ETHYL 2,4-DIPHENYL-5-PYRIMIDINECARBOXYLATE
• Synonyms: ETHYL 2,4-DIPHENYL-5-PYRIMIDINECARBOXYLATE
• CAS NO: 77995-07-4
• Molecular Formula: C₁₉H₁₆N₂O₂
• Molecular Weight: 304.34
• Mol File: 77995-07-4.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ETHYL 2,4-DIPHENYL-5-PYRIMIDINECARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 2,4-DIPHENYL-5-PYRIMIDINECARBOXYLATE(77995-07-4)
• EPA Substance Registry System: ETHYL 2,4-DIPHENYL-5-PYRIMIDINECARBOXYLATE(77995-07-4)

Safety Data

• Hazardous Substances Data: 77995-07-4(Hazardous Substances Data)

Upstream product

• 66129-60-0 ethyl-3-(dimethylamino)-2-(phenylcarbonyl)prop-2-enoate 
• 1670-14-0 benzamidine monohydrochloride 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 53256-19-2 ethyl (Z)-3-amino-3-phenylacrylate 
• 55-21-0 benzamide 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 5720-07-0 4-methoxyphenylboronic acid 

Downstream Products

• 25095-49-2 2,4-diphenylpyrimidine-5-carboxylic acid 
• 25095-48-1 2,4-diphenylpyrimidine 

Relevant articles and documents

Dehydrosulfurative arylation with concomitant oxidative dehydrogenation for rapid access to pyrimidine derivatives

This report describes a cascade reaction method for the synthesis of 2-arylpyrimidine derivatives via dehydrosulfurative carbon-carbon cross-coupling and concomitant oxidative dehydrogenation under a Pd/Cu catalytic system. It provides rapid and general access to a diverse range of 2-arylpyrimidines in a single step from a wide range of 3,4-dihydropyrimidin-1H-2-thiones (DHPMs) and arylboronic acids.

An Improved General Synthesis of 4-Aryl-5-pyrimidinecarboxylates

We wish to report an improved, general synthesis of 4-aryl-5-pyrimidinecarboxylates 1.Two different routes have previously been reported for the synthesis of examples of this class of pyrimidine carboxylates.The parent compound, ethyl 4-phenyl-5-pyrimidinecarboxylate was prepared in low yield by the reaction of s-triazine with ethyl benzoyl acetate.In addition, the enol ether β-ketoaldehyde synthon, ethyl 2-benzoyl-3-ethoxy-2-propenoate, was reported to give 1a in modest yield when reacted with guanidine (2).