78-72-8

Basic information

• Product Name: 2-Ethyl-3-propyloxirane-2-methanol
• Synonyms: 2-Ethyl-3-propyloxirane-2-methanol
• CAS NO: 78-72-8
• Molecular Formula: C8H16O2
• Molecular Weight: 144.2114
• Mol File: 78-72-8.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 205.3°Cat760mmHg
• Flash Point: 73.9°C
• Appearance: /
• Density: 0.942g/cm³
• Vapor Pressure: 0.0601mmHg at 25°C
• Refractive Index: 1.439
• CAS DataBase Reference: 2-Ethyl-3-propyloxirane-2-methanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Ethyl-3-propyloxirane-2-methanol(78-72-8)
• EPA Substance Registry System: 2-Ethyl-3-propyloxirane-2-methanol(78-72-8)

Safety Data

• Hazardous Substances Data: 78-72-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H16O2/c1-3-5-7-8(4-2,6-9)10-7/h7,9H,3-6H2,1-2H3

Upstream product

• 90112-78-0 2-ethyl-3-propyloxirane-2-carbaldehyde 
• 64344-45-2 (E)-2-ethyl-2-hexenal 
• 1235457-83-6 (2R,3S)-2-ethyl-3-propyloxirane-2-carbaldehyde 

Relevant articles and documents

The cinchona primary amine-catalyzed asymmetric epoxidation and hydroperoxidation of α,β-unsaturated carbonyl compounds with hydrogen peroxide

Using cinchona alkaloid-derived primary amines as catalysts and aqueous hydrogen peroxide as the oxidant, we have developed highly enantioselective Weitz-Scheffer-type epoxidation and hydroperoxidation reactions of α,β-unsaturated carbonyl compounds (up to 99.5:0.5 er). In this article, we present our full studies on this family of reactions, employing acyclic enones, 5-15-membered cyclic enones, and α-branched enals as substrates. In addition to an expanded scope, synthetic applications of the products are presented. We also report detailed mechanistic investigations of the catalytic intermediates, structure-activity relationships of the cinchona amine catalyst, and rationalization of the absolute stereoselectivity by NMR spectroscopic studies and DFT calculations.