78009-13-9Relevant articles and documents
2-Position-Selective Trifluoromethylthiolation of Six-Membered Heteroaromatic Compounds
Muta, Ryuhei,Torigoe, Takeru,Kuninobu, Yoichiro
supporting information, (2019/06/13)
The regioselective C-H trifluoromethylthiolation of six-membered heteroaromatic compounds via nucleophilic attack of a CF3S source on the electrophilically activated six-membered heteroaromatic ring was developed. The reaction proceeds in good yield with good functional group tolerance, even on a gram-scale. The key to the successful regioselective transformation is the presence of an additive (2,4-dinitrobenzenesulfonyl chloride). The regioselective trifluoromethylthiolation of quinidine derivative is also demonstrated. Trifluoromethylthiolation, followed by S-oxidation, affords the corresponding sulfones.
An approach to pyrimidine N-oxides: Carboxamide oximes as precursors
Mlakar, Biserka,?tefane, Bogdan,Ko?evar, Marijan,Polanc, Slovenko
, p. 961 - 973 (2007/10/03)
A method for the synthesis of pyrimidines N-oxides is described. Various carboxamide oximes were treated with the appropriate 1,3-dicarbonyl compounds or their equivalents in the presence of trifluoroacetic acid as a catalyst to give the corresponding pyr
OXIDATION OF 2,4-DISUBSTITUTED PYRIMIDINES WITH ORGANIC PERACIDS
Yamanaka, Hiroshi,Ogawa, Shigeru,Sakamoto, Takao
, p. 573 - 576 (2007/10/02)
While 4,6-disubstituted (alkyl, aryl, alkoxyl) pyrimidines easily afforded the corresponding mono-N-oxides with hydrogen peroxide in glacial acetic acid, pyrimidine derivatives whose 6-position is free, are partly oxidatively degradated during N-oxidation reaction.The oxidation of the latter compounds under the above conditions gave 2,4-disubstituted imidazoles together with their mono-N-oxides.A likely mechanism of this ring-contraction and the improved conditions for the synthesis of the N-oxides are also described.