78025-76-0

Basic information

• Product Name: Acetic acid, [4-[(2,4-diamino-5-pyrimidinyl)methyl]-2,6-dimethoxyphenoxy]-, ethyl ester
• CAS NO: 78025-76-0
• Molecular Formula: C17H22N4O5
• Molecular Weight: 362.385
• Mol File: 78025-76-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Acetic acid, [4-[(2,4-diamino-5-pyrimidinyl)methyl]-2,6-dimethoxyphenoxy]-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Acetic acid, [4-[(2,4-diamino-5-pyrimidinyl)methyl]-2,6-dimethoxyphenoxy]-, ethyl ester(78025-76-0)
• EPA Substance Registry System: Acetic acid, [4-[(2,4-diamino-5-pyrimidinyl)methyl]-2,6-dimethoxyphenoxy]-, ethyl ester(78025-76-0)

Safety Data

• Hazardous Substances Data: 78025-76-0(Hazardous Substances Data)

Upstream product

• 105-36-2 ethyl bromoacetate 
• 21253-58-7 2,4-diamino-5-(3,5-dimethoxy-4-hydroxybenzyl)pyrimidine 

Downstream Products

• 78025-77-1 2-(4-((2,4-diaminopyrimidin-5-yl)methyl)-2,6-dimethoxyphenoxy)acetic acid 

Relevant articles and documents

Receptor-based design of dihydrofolate reductase inhibitors: Comparison of crystallographically determined enzyme binding with enzyme affinity in a series of carboxy-substituted trimethoprim analogues

By the use of molecular models of Escherichia coli dihydrofolate reductase (DHFR), analogues of trimethoprim (TMP) were designed which incorporated various 3'-carboxyalkoxy moieties in order to acquire ionic interactions with positively charged active-sit