78104-41-3

Basic information

• Product Name: 2-acetyl-7-chloro-1,2,3,4-tetrahydroisoquinoline
• Synonyms: 2-acetyl-7-chloro-1,2,3,4-tetrahydroisoquinoline;1-(7-Chloro-3,4-dihydroisoquinolin-2(1H)-yl)ethan-1-one
• CAS NO: 78104-41-3
• Molecular Formula: C11H12ClNO
• Molecular Weight: 209.67208
• Mol File: 78104-41-3.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-acetyl-7-chloro-1,2,3,4-tetrahydroisoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-acetyl-7-chloro-1,2,3,4-tetrahydroisoquinoline(78104-41-3)
• EPA Substance Registry System: 2-acetyl-7-chloro-1,2,3,4-tetrahydroisoquinoline(78104-41-3)

Safety Data

• Hazardous Substances Data: 78104-41-3(Hazardous Substances Data)

Usage

General Description

2-acetyl-7-chloro-1,2,3,4-tetrahydroisoquinoline is a chemical compound with the molecular formula C11H12ClNO. It is a derivative of tetrahydroisoquinoline and contains a chlorine atom and an acetyl group. 2-acetyl-7-chloro-1,2,3,4-tetrahydroisoquinoline has been studied for its potential pharmaceutical properties, particularly in the field of medicinal chemistry and drug discovery. It has been investigated for its potential role in the development of novel drugs for the treatment of various medical conditions. Additionally, it may also be used as a research tool in biological and chemical research, particularly in the study of structure-activity relationships and drug design. Overall, 2-acetyl-7-chloro-1,2,3,4-tetrahydroisoquinoline is a compound of interest in pharmaceutical and scientific research.

Upstream product

• 50-00-0 formaldehyd 
• 88422-94-0 N-<2-(4-chlorophenyl)ethyl>acetamide 
• 140-53-4 p-chlorobenzyl cyanide 
• 156-41-2 4-chlorophenylethylamine 

Downstream Products

• 82771-60-6 7-chloro-1,2,3,4-tetrahydro-isoquinoline 

Relevant articles and documents

The influence of substitution at aromatic part of 1,2,3,4-tetrahydroisoquinoline on in vitro and in vivo 5-HT1A/5-HT2A receptor activities of its 1-adamantoyloaminoalkyl derivatives

Further structure-activity relationship (SAR) studies with the 1,2,3,4-tetrahydroisoquinoline (THIQ) class of 5-HT1A ligands led to the synthesis of new 1-adamantoyloaminoalkyl derivatives. The impact of substituent variations in the aromatic part of THIQ moiety on 5-HT1A and 5-HT2A receptor affinities, as well as in vivo functional properties of the investigated compounds were discussed. It was found that modification reduced the binding affinity for 5-HT1A receptors (in comparison with unsubstituted THIQ derivatives); however, the majority of new compounds still remained potent 5-HT1A ligands (Ki = 4.9-46 nM) and most of them showed features of partial agonists of postsynaptic 5-HT1A receptors. At the same time, their 5-HT2A receptor affinity was slightly increased (Ki = 40-1475 nM), which resulted in a loss of 5-HT2A/5-HT1A selectivity. 5-Br,8-OCH3 derivative - the most potent, mixed 5-HT1A/5-HT2A ligand - produced activation of presynaptic 5-HT1A receptors and showed properties of a 5-HT2A receptor antagonist. Copyright