78167-64-3

Basic information

• Product Name: 2-(1-Methyl-2-pyrrolidinylidene)-Acetic acid ethyl ester
• Synonyms: 2-(1-Methyl-2-pyrrolidinylidene)-Acetic acid ethyl ester;Ethyl (1-methyl-2-pyrrolidinylidene)acetate
• CAS NO: 78167-64-3
• Molecular Formula: C9H15NO2
• Molecular Weight: 169.2209
• Mol File: 78167-64-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 93-95℃ (0.01 Torr)
• Appearance: /
• CAS DataBase Reference: 2-(1-Methyl-2-pyrrolidinylidene)-Acetic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1-Methyl-2-pyrrolidinylidene)-Acetic acid ethyl ester(78167-64-3)
• EPA Substance Registry System: 2-(1-Methyl-2-pyrrolidinylidene)-Acetic acid ethyl ester(78167-64-3)

Safety Data

• Hazardous Substances Data: 78167-64-3(Hazardous Substances Data)

Usage

General Description

2-(1-Methyl-2-pyrrolidinylidene)-Acetic acid ethyl ester is a chemical compound with the molecular formula C11H17NO2. It is commonly used as a reagent in organic synthesis and as a building block in the production of pharmaceuticals. 2-(1-Methyl-2-pyrrolidinylidene)-Acetic acid ethyl ester is derived from acetic acid and ethyl ester and contains a pyrrolidine ring. It is known for its potential as an anti-inflammatory and pain-relieving agent, and it is often used in research and drug development. However, it is important to handle this compound with care, as exposure to large amounts can cause irritation to the skin, eyes, and respiratory system. Proper safety precautions should be taken when working with this chemical.

Upstream product

• 1071-46-1 hydrogen ethyl malonate 
• 25355-40-2 3,4-dihydro-1-methyl-2-(methylthio)-5H-pyrrolium iodide 
• 141-97-9 ethyl acetoacetate 
• 35116-15-5 Dibasic magnesium salt of ethyl hydrogen malonate 
• 105-36-2 ethyl bromoacetate 
• 39650-82-3 2,2-dimethoxy-1-methylpyrrolidine 
• 10441-57-3 1-methyl-pyrrolidine-2-thione 
• 117028-40-7 O-methyl-N-methylpyrrolidonium methylsulfate 
• 872-50-4 1-methyl-pyrrolidin-2-one 

Downstream Products

• 144151-97-3 (E)-2-[1-Methyl-pyrrolidin-(2E)-ylidene]-3-oxo-5-phenyl-pent-4-enoic acid ethyl ester 

Relevant articles and documents

Lactam acetals : Part XXIV reaction with activated haloalkyl compounds with and without zinc

Reaction of 2-alkoxyimmonium methosulfates (2), and of lactam acetals (3) derived therefrom, with α-haloesters in presence of zinc (Reformatsky condition) yielded N-alkyl-2-(α-alkyl-α-alkoxycarbonyl)methylene-l-azacycloalkanes (6), while reaction of 3 with α-haloesters without zinc gave 3-alkoxycarbonylmethyl-l-azacycloalkane-2-one (5). Similar reaction of 2 and 3 with 4-bromoethylquinolin-2-one (4) in presence of zinc gave N-alkyl-2-[4-(2-oxoquinolyl)methylene]-1-azacycloalkanes (7), a key intermediate for the synthesis of antimalarial quinoline-4-methanols.

Synthesis in the Diazasteroid Group. XVIII. Syntheses of the 9,17-Diazasteroid System

A 9,17-diazasteroid system, I, was synthesized from an aminoester, III, and cyclohexanone.Unfortunately the yield was poor.Another 9,17-diazasteroid system, II, was prepared from the condensation product, XVa, of quinoline N-oxide with an active methine compound, IV.Thus, XVa was hydrolyzed, followed by decarboxylation, reduction and cyclization.The yield in each step to II was moderate.Keywords- azasteroid; diazasteroid; quinoline N-oxide; cyclization; Pictet-Spengler reaction; active methylene compound; pyrrolopyridine; quinolylpyrrolidine