78167-68-7

Basic information

• Product Name: Methyl 2-(1-Methyl-2-pyrrolidylidene)acetate
• Synonyms: Methyl 2-(1-Methyl-2-pyrrolidylidene)acetate
• CAS NO: 78167-68-7
• Molecular Formula: C₈H₁₃NO₂
• Molecular Weight: 155.19432
• Mol File: 78167-68-7.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Methyl 2-(1-Methyl-2-pyrrolidylidene)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 2-(1-Methyl-2-pyrrolidylidene)acetate(78167-68-7)
• EPA Substance Registry System: Methyl 2-(1-Methyl-2-pyrrolidylidene)acetate(78167-68-7)

Safety Data

• Hazardous Substances Data: 78167-68-7(Hazardous Substances Data)

Usage

General Description

Methyl 2-(1-Methyl-2-pyrrolidylidene)acetate, also known as N-methyl-2-pyrrolidone, is a chemical compound with the molecular formula C8H15NO2. It is a clear, colorless liquid with a slightly sweet odor. This chemical is commonly used as a solvent in a variety of industrial applications, including pharmaceuticals, petrochemicals, and electronics manufacturing. It is also used as a reactant in organic synthesis and as a cleaning agent. Methyl 2-(1-Methyl-2-pyrrolidylidene)acetate is known for its high solvency power, low volatility, and stability, making it suitable for a wide range of applications. However, it is important to handle this chemical with care, as it can be harmful if not used properly.

Upstream product

• 25355-40-2 3,4-dihydro-1-methyl-2-(methylthio)-5H-pyrrolium iodide 
• 105-45-3 acetoacetic acid methyl ester 
• 872-50-4 1-methyl-pyrrolidin-2-one 
• 2033-24-1 cycl-isopropylidene malonate 
• 86208-87-9 (2,2-dimethyl-5-(1-methylpyrrolidin-2-ylidene)-1,3-dioxane-4,6-dione) 
• 124-41-4 sodium methylate 
• 67-56-1 methanol 
• 104165-17-5 (1-Methyl-pyrrolidin-2-ylidene)-ethenone 
• 51849-20-8 methyl 3-oxo-5-(phenylthio)pentanoate 
• 10441-57-3 1-methyl-pyrrolidine-2-thione 
• 104165-16-4 N-Methyl-2-pyrrolidinylidenemalonic anhydride 

Downstream Products

• 51856-76-9 methyl 2-(1-methylpyrrolidin-2-yl)acetate 

Relevant articles and documents

Novel process for preparing 1-methyl-2-(2-hydroxyethyl)pyrrolidine

The present invention relates to a method for synthesizing 1-methyl-2-(2-hydroxyethyl)pyrrolidine, which is useful as an intermediate of a pharmaceutical. More specifically, the present invention relates to a novel synthesis method which uses metal borohydride as a reducing agent in a process of manufacturing 1-methyl-2-(2-hydroxyethyl)pyrrolidine, which is a target substance, from methyl (2E/Z)-2-(1-methylpyrrolidinyridin-2-ylidene)acetate, wherein the methyl (2E/Z)-2-(1-methylpyrrolidinyridin-2-ylidene)acetate is reduced in two stages sequentially, thereby being able to obtain the target substance with a safe process and cheap cost compared to an existing method.COPYRIGHT KIPO 2020

The efficient process for preparation of methyl (2)-(1-methyl-2-pyrrolidinylidene)acetate

The present invention relates to an excellent method of a production process, which is capable of lowering production costs due to yield improvement, reduction in generating wastewater and waste fluid, and reduction in processing time, regarding a mass production of methyl-(2)-(1-methyl-2-pyrrolidinylidene)acetate in a chemical formula 3 which is an intermediate of 1-methyl-2-(2-hydroxyethyl)pyrrolidin as a useful intermediate of a medical substance in a chemical formula 4 of a synthesis process in a reaction formula 1.COPYRIGHT KIPO 2015

An Efficient Synthesis of Acetylated Bicyclic Hydroxypyrroles from Cyclic Lactams via Flash-Vacuum Pyrolysis of Meldrum's Acid Derivatives

The title compounds 9 were synthesized in three steps from cyclic lactams 2.After treatment of 2a-h with phosgene followed by the addition of Meldrum's acid to the chloroiminium chloride intermediates 3a-h, derivatives 4a-h were isolated in good yields.Compounds 4a-g were quantitatively converted to bicyclic enaminones 7a-g by flash-vacuum pyrolysis in the temperature range 480-600 deg C.In contrast, 4h provided 8h, the hydroxyprrole tautomer of 7h.The reaction takes place through the initial formation of (aminomethylene)ketenes 5a-h followed by a 1,4-hydrogen migration from the carbon adjacent to the nitrogen atom to the central carbon of the cumulenone.The lower temperature (480 deg C) needed for benzyl and N-carboalkoxy derivatives 4e-h in comparison with N-alkyl derivatives 4a-d (600 deg C) is correlated with gas-phase acidity of the migrating hydrogen atom.The hydroxypyrroles 8a-g, tautomers of 7a-g (78), were trapped with acetic anhydride, affording O-acetylated bicyclic hydroxypyrroles 9a-g.