782-74-1

Basic information

• Product Name: 1,2-bis(2-chlorophenyl)hydrazine
• Synonyms: 1,2-bis(2-chlorophenyl)hydrazine;1,2-Bis(2-chlorphenyl)hydrazin;N,N'-Bis-(2-chloro-phenyl)-hydrazine
• CAS NO: 782-74-1
• Molecular Formula: C₁₂H₁₀Cl₂N₂
• Molecular Weight: 253.1272
• EINECS: 212-314-7
• Mol File: 782-74-1.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 280.8°C at 760 mmHg
• Flash Point: 123.6°C
• Appearance: /
• Density: 1.405g/cm³
• Vapor Pressure: 0.0037mmHg at 25°C
• Refractive Index: 1.707
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• CAS DataBase Reference: 1,2-bis(2-chlorophenyl)hydrazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-bis(2-chlorophenyl)hydrazine(782-74-1)
• EPA Substance Registry System: 1,2-bis(2-chlorophenyl)hydrazine(782-74-1)

Safety Data

• Hazardous Substances Data: 782-74-1(Hazardous Substances Data)

Usage

General Description

1,2-bis(2-chlorophenyl)hydrazine is a chemical compound with the molecular formula C12H12Cl2N2. It is a hydrazine derivative, which is a class of compounds that are used in various industrial and research applications. This particular compound is a yellow crystalline solid that is insoluble in water. It is primarily used in the synthesis of pharmaceuticals and agrochemicals, as well as in the production of dyes and pigments. 1,2-bis(2-chlorophenyl)hydrazine is also known to have potential biological activity, and has been studied for its potential use in the treatment of certain medical conditions. However, it is important to handle this compound with care, as it can be toxic and harmful if not used properly.

InChI:InChI=1/C12H10Cl2N2/c13-9-5-1-3-7-11(9)15-16-12-8-4-2-6-10(12)14/h1-8,15-16H

Upstream product

• 88-73-3 2-Chloronitrobenzene 
• 7334-33-0 2,2'-dichloroazobenzene 
• 13556-84-8 2,2'-azoxychlorobenzene 
• 7647-01-0 hydrogenchloride 
• 64-17-5 ethanol 
• 71-43-2 benzene 
• 49795-06-4 (E)-bis(2-chlorophenyl)diazene 
• 91-94-1 3,3'-dichlorobenzidine 
• 13556-84-8 2,2'-dichloroazoxybenzene 
• 95-51-2 o-chloroaniline 
• 117-80-6 2,3-Dichloro-1,4-naphthoquinone 

Downstream Products

• 137182-65-1 4-acetyl-1,2-bis(2-chlorophenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one 
• 55908-54-8 1,2-bis(2-chlorophenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one 
• 7334-33-0 2,2'-dichloroazobenzene 
• 91-94-1 3,3'-dichlorobenzidine 
• 49795-06-4 (E)-bis(2-chlorophenyl)diazene 
• 95-51-2 o-chloroaniline 
• 122-66-7 diphenyl hydrazine 
• 91-94-1 3,3'-dichlorobenzidine HCl 

Relevant articles and documents

Production process of 3, 3'-dichlorobenzidine hydrochloride

The invention relates to a production process of 3, 3'-dichlorobenzidine hydrochloride, which belongs to the field of organic chemical industry, and is characterized in that o-nitrochlorobenzene is used as a main raw material to carry out catalytic hydrogenation reduction reaction, the obtained reduction product is rectified, and then the rectified target product 2, 2-dichlorohydroazobenzene is subjected to transposition and separation to obtain the 3, 3'-dichlorobenzidine hydrochloride. According to the method, zero emission of waste acid in production of 3, 3'-dichlorobenzidine is realized, waste acid pollution is completely eradicated, the key problem restricting production of 3, 3-dichlorobenzidine is solved, the byproduct 2-chloroaniline is realized, the economic benefit is improved, in addition, the production procedures are greatly reduced, the production efficiency is improved, and the energy consumption is reduced.

Visible-light-promoted decarboxylative addition cyclization of: N -aryl glycines and azobenzenes to access 1,2,4-triazolidines

Methods for the synthesis of 1,2,4-triazolidines are scarce. Herein, we report a visible-light-promoted decarboxylative addition cyclization of N-aryl glycines and azobenzenes to access such important compounds. Using commercially available methylene blue (MB) as an organic photocatalyst, the reaction proceeded smoothly in the absence of transition-metal catalysts at ambient temperature, affording the corresponding products, 1,2,4-triaryl 1,2,4-triazolidines, in good to excellent yields. This work demonstrates a new synthetic application of readily available azobenenes and provides a novel strategy for constructing 1,2,4-triazolidines.

Synthesis of novel 1,2-diarylpyrazolidin-3-one–based compounds and their evaluation as broad spectrum antibacterial agents

There is a continuous need to develop new antibacterial agents with non-traditional mechanisms to combat the nonstop emerging resistance to most of the antibiotics used in clinical settings. We identified novel pyrazolidinone derivatives as antibacterial hits in an in-house library screening and synthesized several derivatives in order to improve the potency and increase the polarity of the discovered hit compounds. The oxime derivative 24 exhibited promising antibacterial activity against E. coli TolC, B. subtilis and S. aureus with MIC values of 4, 10 and 20 μg/mL, respectively. The new lead compound 24 was found to exhibit a weak dual inhibitory activity against both the E. coli MurA and MurB enzymes with IC50 values of 88.1 and 79.5 μM, respectively, which could partially explain its antibacterial effect. A comparison with the previously reported, structurally related pyrazolidinediones suggested that the oxime functionality at position 4 enhanced the activity against MurA and recovered the activity against the MurB enzyme. Compound 24 can serve as a lead for further development of novel and safe antibiotics with potential broad spectrum activity.