78210-51-2

Basic information

• Product Name: 2-(1H-PYRROL-1-YLMETHYL)PYRIDINE
• Synonyms: 1-(2-PYRIDYLMETHYL)PYRROLE;2-PYRROL-1-YLMETHYL-PYRIDINE;2-(1H-PYRROL-1-YLMETHYL)PYRIDINE;N-(PYRID-2-YLMETHYL)PYRROLE;1-[(Pyridin-2-yl)methyl]-1H-pyrrole
• CAS NO: 78210-51-2
• Molecular Formula: C₁₀H₁₀N₂
• Molecular Weight: 158.2
• Mol File: 78210-51-2.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 100°C/0.5mm
• Flash Point: 109.6°C
• Appearance: /
• Density: 1.04g/cm³
• Vapor Pressure: 0.0232mmHg at 25°C
• Refractive Index: 1.579
• PKA: 3.33±0.12(Predicted)
• CAS DataBase Reference: 2-(1H-PYRROL-1-YLMETHYL)PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1H-PYRROL-1-YLMETHYL)PYRIDINE(78210-51-2)
• EPA Substance Registry System: 2-(1H-PYRROL-1-YLMETHYL)PYRIDINE(78210-51-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26
• Hazardous Substances Data: 78210-51-2(Hazardous Substances Data)

Usage

General Description

2-(1H-Pyrrol-1-ylmethyl)pyridine is a chemical compound with the molecular formula C11H10N2. It is a heterocyclic compound containing a pyrrole ring and a pyridine ring. 2-(1H-PYRROL-1-YLMETHYL)PYRIDINE is commonly used as a building block in organic synthesis and is a useful intermediate in the production of pharmaceuticals and agrochemicals. It can undergo various chemical reactions, including alkylation, acylation, and oxidation, to produce a wide range of derivatives with potential applications in various industries. 2-(1H-Pyrrol-1-ylmethyl)pyridine is also known for its potential biological activity and is being studied for its potential pharmacological effects.

InChI:InChI=1/C10H10N2/c1-2-6-11-10(5-1)9-12-7-3-4-8-12/h1-8H,9H2

Upstream product

• 696-59-3 cis,trans-2,5-dimethoxytetrahydrofuran 
• 3731-51-9 2-(Aminomethyl)pyridine 
• 1121-60-4 pyridine-2-carbaldehyde 
• 51-35-4 4R-4-hydroxyproline 
• 60032-62-4 2-[(1-Pyrrolidinyl)methyl]pyridine 
• 55401-97-3 2-(Bromomethyl)pyridine 

Downstream Products

• 1198351-43-7 4-[1-(pyridyn-2-ylmethyl)pyrrol-2-yl]benzonitryle 

Relevant articles and documents

An elegant protocol for the synthesis of N-substituted pyrroles through C-N cross coupling/aromatization process using CuFe2O4 nanoparticles as catalyst under ligand-free conditions

A simple and efficient, ligand-free C-N cross-coupling of aryl halides/benzyl bromides with trans-4-hydroxy-l-proline has been developed to produce aromatized N-substituted pyrroles, using a catalytic amount of magnetically separable and recyclable CuFe2O4 nanoparticles, in the presence of Cs2CO3 in DMSO at 100 °C.

A new facile approach to N-alkylpyrroles from direct redox reaction of 4-hydroxy-l-proline with aldehydes

An unprecedented acetic acid-catalyzed efficient access to N-alkylpyrroles from reaction of 4-hydroxy-l-proline with a variety of aldehydes has been achieved in good to excellent yields under mild reaction conditions.

Magnetic Nanoparticle-Supported Glutathione as a Sustainable Organocatalyst

This invention relates to the use of nano-organocatalysts, and, more specifically, to the use of magnetic nanomaterial-supported organocatalysts. It is an object of the present invention to provide “green” catalysts and protocols. According to one embodiment of the invention, a nano-organocatalyst in the form of a magnetic nanomaterial-supported organocatalyst is provided. According to other embodiments of the invention, glutathione and cysteine are provided as organocatalysts and magnetic nanomaterial-supported glutathione and magnetic nanomaterial-supported cysteine are provided for use as nano-organocatalysts. According to another embodiment of the invention, a method of using a recyclable magnetic nanomaterial-supported organocatalyst using a totally benign aqueous protocol, without using any organic solvent in the reaction or during the workup, is provided. According to a further embodiment of the invention, a recyclable magnetic nanomaterial-supported organocatalyst for various organocatalytic reactions, including but not limited to Paal-Knorr reactions, aza-Michael addition and pyrazole synthesis, is provided.