78242-20-3

Basic information

• Product Name: 1-Methyl-1H-pyrazol-4-ol
• Synonyms: 1-Methyl-1H-pyrazol-4-ol;4-Hydroxy-1-methyl-1H-pyrazole;1-methylpyrazol-4-ol;1-METHYL-1H-PYRAZOL-4-OL(WXC09189)
• CAS NO: 78242-20-3
• Molecular Formula: C₄H₆N₂O
• Molecular Weight: 98.10324
• Mol File: 78242-20-3.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 217.7±13.0 °C(Predicted)
• Appearance: /
• Density: 1.22±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 9.19±0.14(Predicted)
• CAS DataBase Reference: 1-Methyl-1H-pyrazol-4-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Methyl-1H-pyrazol-4-ol(78242-20-3)
• EPA Substance Registry System: 1-Methyl-1H-pyrazol-4-ol(78242-20-3)

Safety Data

• Hazardous Substances Data: 78242-20-3(Hazardous Substances Data)

Usage

General Description

1-Methyl-1H-pyrazol-4-ol, also known as 1-Methyl-4-hydroxypyrazole, is a chemical compound with the molecular formula C4H6N2O. It is a heterocyclic compound that belongs to the pyrazole class of chemicals. 1-Methyl-1H-pyrazol-4-ol is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. It has also been studied for its potential use in treating diseases such as cancer and neurodegenerative disorders. 1-Methyl-1H-pyrazol-4-ol is a versatile chemical with various potential applications in the fields of medicine and agriculture, making it an important compound in chemical research and development.

Upstream product

• 761446-44-0 1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 
• 39806-90-1 4-iodo-1-methyl-1H-pyrazole 

Downstream Products

• 81005-92-7 N-[(2-isopropoxy)-phenoxy]-carbonyl-N-[1-methyl-pyrazol-4-yl-oxy]carbonyl-methylamine 
• 871020-87-0 1-methyl-4-(2-chloro-4-nitrophenoxy)-1H-pyrazole 
• 871020-84-7 1-methyl-4-(2-methyl-4-nitrophenoxy)-1H-pyrazole 

Relevant articles and documents

AMINOPYRAZINE COMPOUNDS AS HPK1 INHIBITOR AND THE USE THEREOF

Disclosed herein is an aminopyrazine compound of Formula (I), or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, and pharmaceutical compositions comprising thereof. Also disclosed is a method of treating HPK1 related disorders or diseases by using the compound disclosed herein.

MACROCYCLIC AZOLOPYRIDINE DERIVATIVES AS EED AND PRC2 MODULATORS

The invention relates to modulators of Embryonic Ectoderm Development (EED) and/or Polycomb Repressive Complex 2 (PRC2) useful in the treatment of disorders and diseases associated with EEC and PRC2, being macrocyclic azolopyridine derivatives and compositions thereof of Formula (I), or a pharmaceutically acceptable salt, prodrug, solvate, hydrate, enantiomer, isomer, or tautomer thereof, wherein X1, X2, X3, A1, A2, Y, R1, R2, R3, and R4 are as described herein.

Regioselective palladium-catalyzed C–H arylation of 4-alkoxy and 4-thioalkyl pyrazoles

A methodology for the palladium-catalyzed regioselective C–H arylation of electron rich pyrazoles has been developed. New ligands and mild conditions (70–90 °C) have been identified for this transformation. An intramolecular application of the methodology provided a novel synthetic route for the regioselective synthesis of 1,5-dihydroisochromeno[4,3-c]pyrazoles and 1,5-dihydroisothiochromeno[4,3-c]pyrazoles.