782495-19-6

Basic information

• Product Name: 1-Pyrrolidinecarboxylic acid, 2-[[[(trifluoromethyl)sulfonyl]amino]methyl]-, phenylmethyl ester, (2S)-
• CAS NO: 782495-19-6
• Molecular Formula: C14H17F3N2O4S
• Molecular Weight: 366.361
• Mol File: 782495-19-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1-Pyrrolidinecarboxylic acid, 2-[[[(trifluoromethyl)sulfonyl]amino]methyl]-, phenylmethyl ester, (2S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Pyrrolidinecarboxylic acid, 2-[[[(trifluoromethyl)sulfonyl]amino]methyl]-, phenylmethyl ester, (2S)-(782495-19-6)
• EPA Substance Registry System: 1-Pyrrolidinecarboxylic acid, 2-[[[(trifluoromethyl)sulfonyl]amino]methyl]-, phenylmethyl ester, (2S)-(782495-19-6)

Safety Data

• Hazardous Substances Data: 782495-19-6(Hazardous Substances Data)

Upstream product

• 34079-31-7 Z-Pro-NH₂ 
• 358-23-6 trifluoromethylsulfonic anhydride 
• 119020-03-0 2-(S)-aminomethyl-pyrrolidine-1-carboxylic acid benzyl ester 

Downstream Products

• 782495-18-5 N-(((2S,4R)-4-(tert-butyldimethylsilyloxy)pyrrolidin-2-yl)methyl)-1,1,1-trifluoromethanesulfonamide 

Relevant articles and documents

Direct, highly enantioselective pyrrolidine sulfonamide catalyzed Michael addition of aldehydes to nitrostyrenes

Just can't get enough: The highly versatile pyrrolidine sulfonamide organocatalyst 1, which has been used in α-aminoxylation and Mannich-type reactions, also mediates diastereo- and enantioselective Michael addition reactions of aldehydes and ketones to n

ORGANOCATALYSTS AND METHODS OF USE IN CHEMICAL SYNTHESIS

The present invention pertains generally to compositions comprising organocatalysts that facilitate stereo-selective reactions and the method of their synthesis and use. Particularly, the invention relates to metal-free organocatalysts for facilitation of stereo--selective reactions, and the method of their synthesis and use. These compounds have the structure of the Formulas (I) and (II). Where X is independently selected from CH2, N-Ra, O, S or C=O; Y is CH2, N-Ra, O, S or C=O, with the proviso that at least one of X or Y is CH2, and preferably both of X and Y are CH2; Ra is H, an optionally substituted C1-C12 alkyl, preferably an optionally substituted C1-C6alkyl including a C3-C6 cyclic alkyl group, or an optionally substituted aryl group, preferably an optionally substituted phenyl group; Rb is H, an optionally substituted C1-C12 alkyl, preferably an optionally substituted C1-C6 acyclic or a a C3-C6 cyclic alkyl group, CHO, N(Me)O, CO(S)Ra or the group of Formula (III). Where Rc and Rd are each independently H, F, C1, an optionally substituted C1-C20 alkyl, preferably an optionally substituted C1-C12 alkyl, more preferably a C1-C6 alkyl, and an optionally substituted aryl group, or together Rc and Rd form an optionally substituted carbocyclic or optionally substituted heterocyclic ring; R1 is OH, OR, NR'R", NHC(=O)R, NHSO2R; R2 is H, F, C1, an optionally substituted C1-C20 alkyl, preferably an optionally substituted C1-C6 alkyl, an optionally substituted aryl group or a =O group (which establishes a carbonyl group with the carbon to which =O is attached; R3 is H, OH, F, C1, Br, I, Cl, an optionally substituted C1-C20 alkyl, alkenyl or alkynyl ("hydrocarbyl") group, preferably an optionally substituted C1-C6 alkyl, or an optionally substituted aryl, such that the carbon to which R3 is attached has an R or S configuration; R is H, an optionally substituted C1-C20 alkyl, preferably an optionally substituted C1-C6 alkyl, or an optionally substituted aryl group, R' and R" are each independently H, an optionally substituted C1-C20 alkyl group, preferably an optionally substituted C1-C6 alkyl, or an optionally substituted aryl group; or together R' and R" form an optionally substituted heterocyclic, preferably a 4 to 7 membered optionally substituted heterocyclic group or an optionally substituted heteroaryl ring with the nitrogen to which R' and R" are attached; and wherein said compound is free from a metal catalyst.