783342-33-6Relevant articles and documents
PYRAZOLOPYRIDINE PYRAZOLOPYRIMIDINE AND RELATED COMPOUNDS
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Paragraph 0475; 0476, (2015/11/25)
In one aspect this invention relates generally to compounds of Formula: and sub-formulas thereof, or a tautomer of each thereof, a pharmaceutically acceptable salt of each thereof, or a pharmaceutically acceptable solvate of each of the foregoing, where X1, L1, L3, and R3 are described herein.
Estrogen receptor ligands. Part 10: Chromanes: Old scaffolds for new SERAMs
Tan, Qiang,Blizzard, Timothy A.,Morgan II, Jerry D.,Birzin, Elizabeth T.,Chan, Wanda,Yang, Yi Tien,Pai, Lee-Yuh,Hayes, Edward C.,Dasilva, Carolyn A.,Warrier, Sudha,Yudkovitz, Joel,Wilkinson, Hilary A.,Sharma, Nandini,Fitzgerald, Paula M.D.,Li, Susan,Colwell, Lawrence,Fisher, John E.,Adamski, Sharon,Reszka, Alfred A.,Kimmel, Donald,Dininno, Frank,Rohrer, Susan P.,Freedman, Leonard P.,Schaeffer, James M.,Hammond, Milton L.
, p. 1675 - 1681 (2007/10/03)
The discovery, synthesis, and SAR of chromanes as ERα subtype selective ligands are described. X-ray studies revealed that the origin of the ERα-selectivity resulted from a C-4 trans methyl substitution to the cis-2,3-diphenyl-chromane platform. Selected
